Results 61 to 70 of about 11,013,611 (366)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Endometrial stem/progenitor cells [PDF]

Journal of Obstetrics and Gynaecology Research, 2014
AbstractHuman endometrium regenerates and regresses with each menstrual cycle under hormonal control throughout a woman's reproductive life. The cyclical regeneration and remodeling potentials allude to the existence of stem/progenitor cells in the endometrium.
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Flow Cytometric Determination of Circulating Progenitor Cells in Patients With Pulmonary Arterial Hypertension: A Systematic Review

Pulmonary Circulation
Pulmonary arterial hypertension (PAH) is characterized by progressive narrowing and obliteration of distal, pre‐capillary pulmonary vessels. Yet, noninvasive biomarkers that reflect this disease‐defining process are lacking.
Kimia Heydari, Carrie Johnson, I. Diane Cooper, Kadija Hersi, Carl Tanba, Junfeng Sun, Michael A. Solomon, Jason M. Elinoff   +7 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Biotechnology and Cytotherapeutics: The Swiss Progenitor-Cell Transplantation Program

Encyclopedia, 2022
Historically, primary human progenitor cells (e.g., WI-38 and MRC-5 diploid-cell sources) have been industrially applied in research and in manufacturing processes for vaccines and for biologicals.
Alexis Laurent, Corinne Scaletta, Philippe Abdel-Sayed, Murielle Michetti, Anthony de Buys Roessingh, Wassim Raffoul, Nathalie Hirt-Burri, Lee Ann Applegate   +7 more
doaj   +1 more source

Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury

Journal of Neuroscience, 2005
Demyelination contributes to loss of function after spinal cord injury, and thus a potential therapeutic strategy involves replacing myelin-forming cells.
H. Keirstead, G. Nistor, G. Bernal, Minodora O. Totoiu, Frank Cloutier, K. Sharp, O. Steward   +6 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Altered Erythro-Myeloid Progenitor Cells Are Highly Expanded in Intensively Regenerating Hematopoiesis

Frontiers in Cell and Developmental Biology, 2020
Regeneration of severely damaged adult tissues is currently only partially understood. Hematopoietic tissue provides a unique opportunity to study tissue regeneration due to its well established steady-state structure and function, easy accessibility ...
Kateřina Faltusová, Chia-Ling Chen, Tomáš Heizer, Tomáš Heizer, Martin Báječný, Katarina Szikszai, Petr Páral, Filipp Savvulidi, Nicol Renešová, Nicol Renešová, Emanuel Nečas, Emanuel Nečas   +11 more
doaj   +1 more source

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states

Scientific Reports, 2021
Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
doaj   +1 more source