Results 101 to 110 of about 328,870 (293)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

Physiologie de la reproduction et endocrinologie chez les cervidés : une revue [PDF]

, 2003
peer reviewedKnowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract, length of breeding season, parameters ...
Balligand, Marc, Bauvir, Etienne, Beckers, Jean-François, Collin, Bernard, Drion, Pierre, Gabriel, Annick, Hanzen, Christian, Leboeuf, Bernard, Ropstad, Eric, Wirth, Delphine - in memoriam   +9 more
core  

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

A questionnaire-based audit to assess overall experience and convenience among patients using vaginal progesterone tablets (Lutigest®) for luteal phase support during IVF treatment

Patient Related Outcome Measures, 2017
Polly Heine,1 Laura Sellar,1 Sue Whitten,2 Priti Bajaj2 1Fertility Team, The Agora Gyneacology and Fertility Centre, Hove, 2Medical Affairs, Ferring Pharmaceuticals, West Drayton, UK Purpose: The aim of this audit was to assess the overall experience and
Heine P, Sellar L, Whitten S, Bajaj P
doaj  

Vaginal versus intramuscular progesterone in the prevention of preterm labor and their effect on uterine and fetal blood flow

Middle East Fertility Society Journal, 2012
Objectives: To compare vaginal with intramuscular progesterone administration to prevent preterm labor and to detect the effect of both on the uterine and fetal circulations. Study design: Prospective comparative clinical trial.
Azza A. Abd El Hameed
doaj   +1 more source

Conséquences à long terme d'une restriction de croissance intra-utérine sur l'axe reproducteur du rat [PDF]

, 2006
Mémoire numérisé par la Direction des bibliothèques de l'Université de ...
Gaudet, Rébecca
core   +1 more source

La dépression post-natale : les facteurs socio-environnementaux [PDF]

, 1991
Au cours des semaines et des mois qui suivent la naissance, de 10 % à 20 % des mères présentent des symptômes dépressifs modérés ou graves. Cet état de détresse psychologique influe sur l'interaction de la mère avec son nourrisson et peut modifier à plus
Cossette, Louise, Séguin, Louise
core   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis

Cancer Reports
Background Progesterone rapidly induces ovarian cancer cell death through non‐genomic actions mediated by the membrane progesterone receptor (mPR). Aims We investigated the combined effects of progesterone and SN38, an active metabolite of irinotecan, on
Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Eri Suizu, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Hiroaki Mizukami, Hiroyuki Fujiwara   +9 more
doaj   +1 more source

Diabète et troubles de la production de la testostérone chez l'homme [PDF]

, 2015
Introduction: La prévalence du diabète de type 2 augmente rapidement avec une estimation à 17% chez les hommes âgés de plus de 55 ans en Europe. Il semblerait que ces hommes diabétiques de type 2 présentent également un hypogonadisme, mécanisme ...
JEANMONOD, M.
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