Results 111 to 120 of about 13,996 (187)

Le rôle de la progestérone dans la prévention des accouchements prématurés

open access: yes, 2012
L'accouchement prématuré est le principal problème de santé publique en obstétrique. A côté des tocolytiques classiques, la progestérone a commencé à être utilisée depuis une dizaine d'années.
LECLERC, Sandra, POULAIN, Patrice
core  

Zuranolone: A case study in (regulatory) rush to judgement?

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove   +4 more
wiley   +1 more source

Systemic menopausal hormone therapy treatment patterns in Danish women—A nationwide drug utilization study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Objectives This paper aims to describe the treatment patterns of contemporary systemic menopausal hormone therapy (MHT) in Denmark. Study design This study is a nationwide drug utilization study including an open cohort of all Danish women aged >40 years between 2000–2024.
Hannah K. Wood‐Kurland   +7 more
wiley   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Effets de la progestérone et des progestatifs de synthèse sur les cellules mammaires normales et cancéreuses

open access: yes, 2010
Les effets biologiques des progestatifs sur la glande mammaire sont controversés. Les études in vivo décrivent une action antiproliférative et différenciatrice de la progestérone sur la glande mammaire normale.
GOMPEL, Anne, COURTIN, Aurélie
core  

Effect de la progestérone sur la jonction utéro-tubaire et la fécondation chez le chien

open access: yes, 2015
The physiology of reproduction in dogs has several peculiarities, when compared to other mammals. The oocytes are ovulated at an immature stage (germinal vesicle, not fertilizable) and reach the metaphase II stage in the oviduct 3-4 days after ovulation.
Beaufils, Sophie
core   +1 more source

Variations de la LH, de la FSH, du 17 ß oestradiol et de la progestérone au cours du cycle oestral de la chienne [PDF]

open access: yes, 1979
peer reviewedPlasma levels of progesterone, 17-beta-oestradiol, LH and FSH were measured by radioimmunoassay in five beagle bitches during two consecutive estrous cycles.
De Coster, R.   +3 more
core   +1 more source

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang   +16 more
wiley   +1 more source

Fonctions de la voie p39Mos-Xp42Mpk1 dans la reprise de la méiose, la morphogenèse du fuseau et la phosphorylation de Raf induites par la progestérone ou l'insuline dans les ovocytes de xénope

open access: yes, 2004
La reprise méiotique des ovocytes de Xénope est stimulée par la progestérone ou l'insuline. Les ovocytes subissent la rupture de l'enveloppe nucléaire, la condensation des chromosomes et la formation du fuseau méiotique. Durant la méiose, le MPF (Facteur
BAERT, Frédéric, VILAIN, Jean-Pierre
core  

Unbound Intrinsic Formation Clearance of 6β‐Hydroxycortisol Is a Useful Biomarker of CYP3A4 Activity during Pregnancy

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Pregnancy results in multiple physiological changes that impact drug disposition. For example, hepatic CYP3A activity and renal transporter‐mediated clearance increase in late pregnancy, but the time course of these changes across pregnancy is not known.
Aurora K Authement   +3 more
wiley   +1 more source

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