Results 111 to 120 of about 328,870 (293)

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

open access: yesAdvanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu   +9 more
wiley   +1 more source

Reprise de l'activité sexuelle post partum chez les bovins allaitants en Nouvelle-Calédonie [PDF]

open access: yes, 1991
En Nouvelle-Calédonie, au cours d'une saison de reproduction, 108 vaches (61 Charolaises et 37 Santa-Gertrudis) ont subi trois séries mensuelles de deux prises de sang, à 10 jours d'intervalle, de mars à juin.
Bergès, Jean-Michel   +3 more
core  

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang   +10 more
wiley   +1 more source

Maîtrise de la fécondité et planification familiale au Sud [PDF]

open access: yes, 2000
En Guadeloupe, l'avortement est légalisé depuis 1975, mais il était déjà largement pratiqué auparavant. Les avortements clandestins représentent encore un tiers du total des avortements et l'ensemble de ces avortements représentent également 40% des ...
Bangou, J., Guengant, Jean-Pierre
core  

Un aperçu de DRAG, un modèle de sécurité routière compréhensif [PDF]

open access: yes, 1993
Nous faisons un résumé surtout qualitatif de DRAG, un modèle explicatif de la Demande Routière, des Accidents et de leur Gravité. Nous montrons le caractère compréhensif du modèle, en ce qui a trait à sa structure, aux catégories de facteurs explicatifs ...
Gaudry, Marc
core   +1 more source

Progesterone and allopregnanolone in the central nervous system: Response to injury and implication for neuroprotection

open access: yesJournal of Steroid Biochemistry and Molecular Biology, 2015
Progesterone is a well-known steroid hormone, synthesized by ovaries and placenta in females, and by adrenal glands in both males and females. Several tissues are targets of progesterone and the nervous system is a major one. Progesterone is also locally
R. Guennoun   +5 more
semanticscholar   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

open access: yesAdvanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han   +16 more
wiley   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

open access: yesAdvanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu   +4 more
wiley   +1 more source

Le syndrome des ovaires polykystiques chez les adolescentes obèses [PDF]

open access: yes, 2015
Introduction : Le syndrome des ovaires polykystiques (polycystic ovarian syndrome, PCOS) est la pathologie endocrinienne la plus fréquente chez les femmes en âge de procréer avec une prévalence estimée à plus de 8 % (1).
AMETI, A.
core  

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu   +9 more
wiley   +1 more source

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