Results 131 to 140 of about 328,870 (293)

Divergent behavior of cyclin E and its low molecular weight isoforms to progesterone-induced growth inhibition in MCF-7 cells

open access: yesAdvanced Biomedical Research, 2015
Background: Progesterone is a steroid hormone that modulates proliferation and differentiation in a cell phase and tissue-specific manner. Its function in breast cancer cells is of great significance since it can predict susceptibility of tumor cells to ...
Hamed Montazeri   +4 more
doaj   +1 more source

Treatment of breast cancer: Imo State Nigeria versus Indiana, USA women -- comparative analytic study [PDF]

open access: yes, 2014
BACKGROUND: Women with breast cancer undergo multimodal treatment for best outcome. This study seeks to identify the treatment challenges for such women in Imo State, Nigeria vis-à-vis similar women in Indiana USA. We compared the treatment modalities
Anele, A.A.   +5 more
core  

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

open access: yesArthritis &Rheumatology, EarlyView.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty   +4 more
wiley   +1 more source

Main factors associated with variability in the assessment of the objective response rate. A re‐analysis of the PHEREXA phase 3 clinical trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele   +3 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove   +4 more
wiley   +1 more source

Controlling reproduction in organic sheep breeding: the influence of breeding factors on the effectiveness of the ram effect [PDF]

open access: yes, 2009
The ram effect, which is a natural method for the control of reproduction in sheep, is an alternative to hormone treatments that are banned on organic farms.
BOCQUIER, F.   +2 more
core  

Etude des chaleurs des vaches trypanotolérantes Ndama et Baoulé en Côte-d'Ivoire. I. Particularités des composantes comportementale et organique [PDF]

open access: yes, 1991
Pendant l'année 1987, 11 vaches Ndama et 19 vaches Baoulé ont été maintenues en station avec deux vaches androgénisées munies d'un harnais marqueur. Le comportement sexuel a été suivi chaque jour durant 30 min vers 7 h et 15 h 30.
Meyer, Christian, Yesso, P.
core  

Toward personalized healthcare: Advances in two‐dimensional nanomaterial‐based flexible electrochemical sensors for physiological monitoring

open access: yesBMEMat, EarlyView.
This review provides an overview of the properties, composites and application of two‐dimensional (2D) nanomaterials for wearable electrochemical biosensors. Also, the challenges and future prospects of utilizing 2D nanomaterials in wearable electrochemical biosensor applications are discussed.
Kou Zhang   +8 more
wiley   +1 more source

Effets oestrogéniques du macéré aqueux des feuilles de Holarrhena floribunda (G. Don) Dur & Schinz chez la rate ovariectomisée [PDF]

open access: yes, 2006
Oestrogenic effects of macerated aqueous extracts of the leaves of Holarrhena fl oribunda (G. Don) Dur & Schinz on ovariectomized rat. Estrogenic effects of aqueous extracts of leaves of Holarrhena fl oribunda have been evaluated by uterotrophic assay.
Bayala B.   +7 more
core  

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