Results 41 to 50 of about 328,870 (293)

Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial

The Lancet, 2016
Summary Background Progesterone administration has been shown to reduce the risk of preterm birth and neonatal morbidity in women at high risk, but there is uncertainty about longer term effects on the child.
J. Norman, N. Marlow, C. Messow, A. Shennan, P. Bennett, S. Thornton, S. Robson, A. McConnachie, S. Petrou, N. Sebire, T. Lavender, Sonia Whyte, J. Norrie   +12 more
semanticscholar   +1 more source

Androgens Tend to Be Higher, but What about Altered Progesterone Metabolites in Boys and Girls with Autism?

Life, 2022
Background: Evidence exists that steroid hormones are altered in individuals with autism, especially androgens. Despite lower prevalence in girls than boys, evidence of potential alterations in progesterone metabolites is sparse, so the aim of this study
Benedikt Gasser, Johann Kurz, Genevieve Escher, Hiten D. Mistry, Markus G. Mohaupt   +4 more
doaj   +1 more source

Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta‐analysis

American Journal of Obstetrics and Gynecology, 2018
BACKGROUND: An indirect comparison meta‐analysis published in 2013 reported that both vaginal progesterone and cerclage are equally efficacious for preventing preterm birth and adverse perinatal outcomes in women with a singleton gestation, previous ...
A. CONDE-AGUDELO, R. Romero, E. Da Fonseca, J. O'Brien, E. Cetingoz, G. Creasy, S. Hassan, O. Erez, P. Pacora, K. Nicolaides   +9 more
semanticscholar   +1 more source

The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats

Frontiers in Aging Neuroscience, 2015
In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the maternal amnesia phenomenon as well as in controlled experiments.
B. Blair Braden, B. Blair Braden, B. Blair Braden, Melissa L. Kingston, Elizabeth eWhitton, Courtney N. Lavery, Candy W.S. Tsang, Heather Allyson Bimonte-Nelson, Heather Allyson Bimonte-Nelson   +8 more
doaj   +1 more source

Estrogen and progesterone promote breast cancer cell proliferation by inducing cyclin G1 expression

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018
Breast cancer is the most common cause of cancer among women in most countries (WHO). Ovarian hormone disorder is thought to be associated with breast tumorigenesis.
Jintao Tian, B. Ran, C. Zhang, D. Yan, X-H. Li   +4 more
semanticscholar   +1 more source

Effect of slightly elevated progesterone on hCG trigger day on clinical pregnancy rate in GnRH-ant IVF/ICSI cycles

Reproductive Health, 2022
Background It was been agreed that significantly elevated progesterone level on the hCG trigger day have detrimental effect on clinical outcomes in IVF/ICSI cycles.
Jing Zhao, Jie Hao, Bin Xu, Yonggang Wang, Yanping Li   +4 more
doaj   +1 more source

The high concentration of progesterone is harmful for endometrial receptivity and decidualization

Scientific Reports, 2018
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics.
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-huan Liang, Yong-Sheng Fu, Xiaowei Gu, Zeng-Ming Yang   +6 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Initiating luteal phase support with sc progesterone based on low serum progesterone on the transfer day in true natural cycle frozen embryo transfers

Frontiers in Endocrinology, 2023
IntroductionConcerning contemporary in-vitro fertilisation (IVF) practice, the use of frozen embryo transfer (FET) cycles has become more common than fresh transfers.
Cem Demirel, Pınar Özcan, Fırat Tülek, Hikmet Tunç Timur, Özge Pasin   +4 more
doaj   +1 more source