Results 71 to 80 of about 362,542 (345)

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

Advanced Healthcare Materials, EarlyView.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source

Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF. [PDF]

PLoS ONE, 2018
In recent years there is increasing evidence that elevated progesterone levels during ovarian stimulation for IVF / ICSI have a negative impact on the ART-outcome.
Barbara Lawrenz, Junard Sibal, Nicolas Garrido, Emmanuel Abu, Alliza Jean, Laura Melado, Human M Fatemi   +6 more
doaj   +1 more source

Progesterone receptors, their isoforms and progesterone regulated transcription [PDF]

Molecular and Cellular Endocrinology, 2012
This review discusses mechanisms by which progesterone receptors (PR) regulate transcription. We examine available data in different species and tissues regarding: (1) regulation of PR levels; and (2) expression profiling of progestin-regulated genes by total PRs, or their PRA and PRB isoforms.
Kathryn B. Horwitz, Britta M. Jacobsen
openaire   +2 more sources

The impact of micronized progesterone on the endometrium: a systematic review

Climacteric, 2016
Postmenopausal women with an intact uterus using estrogen therapy should receive a progestogen for endometrial protection. International guidelines on menopausal hormone therapy (MHT) do not specify on progestogen type, dosage, route of application and ...
P. Stute, J. Neulen, L. Wildt
semanticscholar   +1 more source

XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

Advanced Science, EarlyView.
Elevated spliced form of X‐box–binding protein 1 (XBP1) correlates with unfavorable responses to endocrine therapy plus CDK4/6 inhibitors in HR+/HER2− advanced breast cancer. XBP1s facilitates cell proliferation and G1/S transition by transcriptionally activating SND1, thereby activating the E2F1 pathway.
Yuting Sang, Shiyang Liu, Xujie Zhou, Weiru Chi, Min Xiong, Ming Chen, Hengyu Ren, Douwaner Liu, Liyi Zhang, Jingyan Xue, Yayun Chi, Jiong Wu   +11 more
wiley   +1 more source

A questionnaire-based audit to assess overall experience and convenience among patients using vaginal progesterone tablets (Lutigest®) for luteal phase support during IVF treatment

Patient Related Outcome Measures, 2017
Polly Heine,1 Laura Sellar,1 Sue Whitten,2 Priti Bajaj2 1Fertility Team, The Agora Gyneacology and Fertility Centre, Hove, 2Medical Affairs, Ferring Pharmaceuticals, West Drayton, UK Purpose: The aim of this audit was to assess the overall experience and
Heine P, Sellar L, Whitten S, Bajaj P
doaj  

Progesterone

, 2023
Progesterone Progesterone is primarily known as the pregnancy hormone in females, and most of its function relates to maintaining pregnancy specifically by preparing the endometrium, decreasing myometrial contractions for implantation, promoting gestation, and inhibition of lactation during pregnancy.
openaire   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis

Cancer Reports
Background Progesterone rapidly induces ovarian cancer cell death through non‐genomic actions mediated by the membrane progesterone receptor (mPR). Aims We investigated the combined effects of progesterone and SN38, an active metabolite of irinotecan, on
Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Eri Suizu, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Hiroaki Mizukami, Hiroyuki Fujiwara   +9 more
doaj   +1 more source

Vaginal versus intramuscular progesterone in the prevention of preterm labor and their effect on uterine and fetal blood flow

Middle East Fertility Society Journal, 2012
Objectives: To compare vaginal with intramuscular progesterone administration to prevent preterm labor and to detect the effect of both on the uterine and fetal circulations. Study design: Prospective comparative clinical trial.
Azza A. Abd El Hameed
doaj   +1 more source