Results 91 to 100 of about 413,118 (356)

Progesterone receptors, their isoforms and progesterone regulated transcription [PDF]

Molecular and Cellular Endocrinology, 2012
This review discusses mechanisms by which progesterone receptors (PR) regulate transcription. We examine available data in different species and tissues regarding: (1) regulation of PR levels; and (2) expression profiling of progestin-regulated genes by total PRs, or their PRA and PRB isoforms.
Britta M, Jacobsen, Kathryn B, Horwitz
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Inhibition of diacylglycerol–sensitive TRPC channels by synthetic and natural steroids [PDF]

, 2012
TRPC channels are a family of nonselective cation channels that regulate ion homeostasis and intracellular Ca2+ signaling in numerous cell types. Important physiological functions such as vasoregulation, neuronal growth, and pheromone recognition have ...
Kleemann, Heinz-Werner, Rütten, Hartmut, Hartmut Rütten (171202), Löhn Matthias, Thorsten Schmidt (5598), Thomas Licher (171199), Löhn, Matthias, Miehe Susanne, Dittrich Werner, Peter Crause, Carsten Strübing (171204), Schmidt, Thorsten, Miehe, Susanne, Susanne Miehe, Schmidt Thorsten, Carsten Strübing, Heinz-Werner Kleemann (171197), Peter Crause (171193), Dittrich, Werner, Licher, Thomas, Hartmut Rütten, Matthias Löhn, Strübing, Carsten, Rütten Hartmut, Matthias Löhn (171195), Strübing Carsten, Werner Dittrich, Licher Thomas, Thomas Licher, Heinz-Werner Kleemann, Werner Dittrich (171200), Kleemann Heinz-Werner, Crause, Peter, Susanne Miehe (171189), Crause Peter, Thorsten Schmidt   +35 more
core   +1 more source

Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma

Cell Death and Disease, 2021
Progesterone resistance can significantly restrict the efficacy of conservative treatment for patients with endometrial cancer who wish to preserve their fertility or those who suffer from advanced and recurrent cancer.
Xiaohong Ma, Tianyi Zhao, Hong Yan, Kui Guo, Zhiming Liu, Lina Wei, Wei Lu, Chunping Qiu, Jie Jiang   +8 more
doaj   +1 more source

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

The role of progesterone in prevention of preterm birth [PDF]

, 2009
Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants.
Caroline A Crowther, Crowther, C., null Crowther, Jodie Dodd, Jodie M Dodd, Dodd, J.   +5 more
core   +1 more source

Progesterone and neurology

Gynecological Endocrinology, 1999
Neurological diseases are frequently observed in perimenopausal women and can be characterized by their gender-specific occurrence. These observations raise the question whether sex steroids are also involved in neurological diseases. Epidemiological data have shown that in Austria in 1993, the prescription rate of psychotropics, hypnotics, and ...
D M, Gruber, M O, Sator, F, Wieser, C, Worda, J C, Huber   +4 more
openaire   +2 more sources

Conjugated Metal‐Organic Frameworks on Laser‐Induced‐Graphene Scaffold Enable Picomolar Sensitivity in Electrical Biosensors

Advanced Materials Interfaces, EarlyView.
A controlled layer‐by‐layer growth process integrates conjugated metal‐organic framework thin films onto a hierarchical 3D laser‐induced graphene scaffold. When incorporated into an extended‐gate field‐effect transistor configuration, this synergistic hybrid platform achieves robust aptamer immobilization, driving highly selective, picomolar‐level ...
Khanh T. M. Le, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +2 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source