Results 71 to 80 of about 413,118 (356)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Progesterone activation of β1-containing BK channels involves two binding sites

Nature Communications, 2023
Progesterone (≥1 µM) is used in recovery of cerebral ischemia, an effect likely contributed to by cerebrovascular dilation. The targets of this progesterone action are unknown.
Kelsey C. North, Andrew A. Shaw, Anna N. Bukiya, Alex M. Dopico   +3 more
doaj   +1 more source

Estrogen and progesterone promote breast cancer cell proliferation by inducing cyclin G1 expression

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018
Breast cancer is the most common cause of cancer among women in most countries (WHO). Ovarian hormone disorder is thought to be associated with breast tumorigenesis.
Jintao Tian, B. Ran, C. Zhang, D. Yan, X-H Li   +4 more
semanticscholar   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ewe-lamb bonding behaviours at birth are affected by maternal undernutrition in pregnancy [PDF]

, 2003
Maternal undernutrition in pregnancy results in low birth-weights and impaired postnatal survival in sheep. Largely anecdotal evidence suggests that the expression of appropriate maternal and neonate behaviours may also be disrupted by undernutrition. In
Dwyer, CM; id_orcid, Lawrence, Alistair, Lawrence, AB; id_orcid, Bishop, SC, Lewis, M, Dwyer, CM   +5 more
core   +1 more source

Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats

Scientific Reports, 2017
Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of GnRH/LH release,
Wen He, Xiaofeng Li, Daniel Adekunbi, Yali Liu, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Progesterone and Follicle Stimulating Hormone interact and promote goat preantral follicles survival and development in vitro

Pesquisa Veterinária Brasileira, 2012
We investigated the effects of progesterone and follicle stimulating hormone (FSH) on survival and growth of caprine preantral follicles. Pieces of ovarian tissue were cultured for 1 or 7 days in minimum essential medium (MEM) alone or containing ...
Isabel B. Lima-Verde, Maria H.T. Matos, Juliana J.H. Celestino, Rafael Rossetto, Khesller P.O. Name, Sônia N. Báo, Cláudio C. Campello, José R. Figueiredo   +7 more
doaj   +1 more source

The high concentration of progesterone is harmful for endometrial receptivity and decidualization

Scientific Reports, 2018
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics.
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-huan Liang, Yong-Sheng Fu, Xiaowei Gu, Zeng-Ming Yang   +6 more
semanticscholar   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone

Science, 2016
Progesterone signaling in sperm Cumulus cells surrounding the ovulated egg release the female hormone progesterone, which is necessary for sperm activation in mammals. Miller et al.
Melissa R. Miller, N. Mannowetz, A. Iavarone, Rojin Safavi, Elena O. Gracheva, James F. Smith, Rose Z. Hill, D. Bautista, Yuriy Kirichok, P. Lishko   +9 more
semanticscholar   +1 more source