Results 101 to 110 of about 30,715 (288)

Metformin Reverses Progestin Resistance in Endometrial Cancer Cells by Downregulating GloI Expression

open access: yes, 2011
Introduction:A long-term treatment with progestin commonly results in progestin resistance in endometrial cancer. So, the aim of this study was to investigate the role of glyoxalase I (GloI), a mediator of chemotherapy resistance, in metformin reversal ...
Zhenbo Zhang   +7 more
core   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

open access: yesPrecision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang   +7 more
wiley   +1 more source

Progestin-based pharmacotherapy in fertility preservation in early endometrial cancer

open access: yesFrontiers in Oncology
Endometrial cancer is a common tumor of the female reproductive system. In recent years, as the age of onset of the disease has gradually become younger, this has caused distress to some young patients with reproductive needs, and the active search for ...
Zhendong Qin   +3 more
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

open access: yesPhytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao   +11 more
wiley   +1 more source

Effectiveness of Intrauterine Levonorgesterel-Releasing Device in the Treatment of Endometrial Hyperplasia in Obese Patients

open access: yesActa Medica Alanya
Aim: Endometrial hyperplasia (EH) is a precursor lesion of endometrial adenocarcinoma, the most common gynecological malignancy in women. Endometrial hyperplasias divided in two groups: non-atypical hyperplasia and atypical hyperplasia.
Işıl Çiçekdağı, Sezin Ateş
doaj  

Fertility-sparing treatment for patients with endometrial cancer: a bibliometric analysis from 2000 to 2024

open access: yesFrontiers in Oncology
IntroductionThe rising global incidence of endometrial cancer (EC), particularly among younger patients, has established fertility-sparing treatment as a critical focus in gynecological and reproductive medicine.
Yue Gao   +4 more
doaj   +1 more source

Differentiating high‐ and low‐grade serous ovarian carcinoma using radiomics: a pilot study

open access: yesUltrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To identify ultrasound‐based radiomics features capable of distinguishing between high‐grade serous ovarian carcinomas (HGSC) and invasive low‐grade serous ovarian carcinomas (LGSC), and to develop machine‐learning models that include radiomics features to discriminate between the two.
F. Ciccarone   +17 more
wiley   +1 more source

Influencing Factors Associated With Infantile Hemangioma: A Case–Control Study Among Chinese Pediatric Populations

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. While its epidemiology is well‐documented in Caucasian populations, large‐scale systematic studies regarding clinical characteristics and risk factors in the Chinese population remain limited.
Xinyu Liu   +4 more
wiley   +1 more source

Long-Term Maintenance of Viable Human Endometrial Epithelial Cells to Analyze Estrogen and Progestin Effects

open access: yesCells
There are fewer investigations conducted on human primary endometrial epithelial cells (HPEECs) compared to human primary endometrial stromal cells (HPESCs). One of the main reasons is the scarcity of protocols enabling prolonged epithelial cell culture.
Muhammad Assad Riaz   +5 more
doaj   +1 more source

Forkhead Transcription Factor FOXO1 is a Direct Target of Progestin to Inhibit Endometrial Epithelial Cell Growth

open access: yes, 2011
Purpose and experimental design: Despite the therapeutic utility of progestin in invasive and preinvasive endometrial neoplasias, the molecular mechanisms through which it exerts inhibitory effects on endometrial epithelial growth are largely unknown ...
Kiyohiko Miyake   +11 more
core   +1 more source

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