Results 21 to 30 of about 68,845 (338)

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.

Journal of the American Medical Association (JAMA), 2002
CONTEXT Despite decades of accumulated observational evidence, the balance of risks and benefits for hormone use in healthy postmenopausal women remains uncertain.
J. Rossouw, G. Anderson, Ross L. Prentice, Andrea Z LaCroix, C. Kooperberg, M. L. Stefanick, R. Jackson, Shirley A A Beresford, Barbara V. Howard, Karen C. Johnson, J. Kotchen, Judith Ockene   +11 more
semanticscholar   +1 more source

Chlorpromazine Sensitizes Progestin-Resistant Endometrial Cancer Cells to MPA by Upregulating PRB

Frontiers in Oncology, 2021
Medroxyprogesterone acetate (MPA) is the main conservative treatment for endometrial cancer (EC) patients desirable to preserve fertility and those who cannot suffer from surgery.
Yunxia Cui, Huiwen Wu, Linlin Yang, Ting Huang, Jian Li, Jian Li, Jian Li, Xiaodi Gong, Lijuan Li, Xiao Sun, Xiao Sun, Fei Mao, Yudong Wang, Yudong Wang   +13 more
doaj   +1 more source

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells [PDF]

, 2005
Interactions between steroid hormone receptors and signal transducer and activator of transcription (Stat)-mediated signaling pathways have already been described.
Carnevale, Romina Paula, Charreau, Eduardo Hernan, Elizalde, Patricia Virginia, Frahm, Isabel, Kornblihtt, Alberto Rodolfo, Molinolo, Alfredo, Pecci, Adali, Proietti Anastasi, Cecilia Jazmín, Rosemblit, Cinthia, Salatino, Mariana, Schillaci, Roxana   +10 more
core   +3 more sources

Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group.

Journal of the American Medical Association (JAMA), 1998
CONTEXT Observational studies have found lower rates of coronary heart disease (CHD) in postmenopausal women who take estrogen than in women who do not, but this potential benefit has not been confirmed in clinical trials.
S. Hulley, D. Grady, T. Bush, C. Furberg, D. Herrington, B. Riggs, E. Vittinghoff   +6 more
semanticscholar   +1 more source

Route-specific association of progestin therapy and concurrent metformin use in obese women with complex atypical hyperplasia

International Journal of Gynecological Cancer, 2020
Introduction Previous studies have suggested that metformin use may enhance the therapeutic effect of progestin therapy for endometrial hyperplasia or malignancy.
K. Matsuo, R. Mandelbaum, M. Ciccone, M. Khoshchehreh, Heena Pursuwani, E. Morocco, S. Matsuzaki, C. Dancz, B. Ozel, R. Paulson, L. Roman   +10 more
semanticscholar   +1 more source

Concomitant contraceptive implant and efavirenz use in women living with HIV: perspectives on current evidence and policy implications for family planning and HIV treatment guidelines. [PDF]

, 2017
IntroductionPreventing unintended pregnancies is important among all women, including those living with HIV. Increasing numbers of women, including HIV-positive women, choose progestin-containing subdermal implants, which are one of the most effective ...
Cohen, Craig R, Kiarie, James, Morroni, Chelsea, Patel, Rena C, Scarsi, Kimberly K, Sripipatana, Tabitha   +5 more
core   +2 more sources

Estrogen plus progestin and the risk of coronary heart disease.

New England Journal of Medicine, 2003
BACKGROUND Recent randomized clinical trials have suggested that estrogen plus progestin does not confer cardiac protection and may increase the risk of coronary heart disease (CHD).
J. Manson, J. Hsia, K. Johnson, J. Rossouw, A. Assaf, N. Lasser, M. Trevisan, H. Black, S. Heckbert, R. Detrano, O. Strickland, N. Wong, J. Crouse, E. Stein, M. Cushman   +14 more
semanticscholar   +1 more source

The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent [PDF]

, 2017
Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study,
Acharya, Kalpana D, Denner, Larry, Edwards, Dean P, Harling, Moriah, Huang, Shixia, Im, Dana D, Lichti, Cheryl F, Nettles, Sabin A, Pattanayak, Cassandra, Sellers, Katherine J, Srivastava, Deepak P, Tetel, Marc J, Vardar-Ulu, Didem   +12 more
core   +3 more sources

Menopausal hormone therapy and central nervous system tumors: Danish nested case-control study.

PLoS Medicine, 2023
BackgroundUse of estrogen-containing menopausal hormone therapy has been shown to influence the risk of central nervous system (CNS) tumors. However, it is unknown how the progestin-component affects the risk and whether continuous versus cyclic ...
Nelsan Pourhadi, Amani Meaidi, Søren Friis, Christian Torp-Pedersen, Lina S Mørch   +4 more
doaj   +1 more source

Germany Endometriosis Pattern Changes; Prevalence and Therapy over 2010 and 2019 Years: A Retrospective Cross Sectional Study [PDF]

International Journal of Fertility and Sterility, 2022
Background: The aim of this study was to investigate whether the prevalence and the therapy patterns of endometriosis differ in 2010 and 2019. Materials and Methods: This retrospective cross-sectional study was based on the data from the IQVIA Disease ...
Jacob Goehring, Maja Drewes, Matthias Kalder, Karel Kostev   +3 more
doaj   +1 more source