Results 101 to 110 of about 14,033 (271)

Risk of Cancer With Hormone Replacement Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Hormone replacement therapy (HRT) remains the cornerstone of menopausal symptom management, effectively alleviating vasomotor symptoms and genitourinary syndrome, whilst mitigating long‐term risks such as osteoporosis. However, despite an increasing body of evidence on the relative safety of HRT, earlier studies that demonstrated an increased ...
Gabriella Yongue, Zachary Nash, Vikram Talaulikar, Shibani Nicum   +3 more
wiley   +1 more source

The action of ovarian hormones in cardiovascular disease

Biological Research, 2003
The incidence of cardiovascular disease (CAD) differs between men and women, in part because of differences in risk factors and hormones. This sexual dimorphism means a lower incidence in atherosclerotic diseases in premenopausal women, which ...
RODOLFO A MEDINA, EVELYN ARANDA, CESAR VERDUGO, SUMIE KATO, GARETH I OWEN   +4 more
doaj  

Non-Steroidal Anti-inflammatory Drugs and Progestins Synergistically Enhance Cell Death in Ovarian Epithelial Cells.

, 1900
Objective: There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis,we investigated the potential for synergistic impact of combined drug treatment on cell death.
Andrew Berchuck (13724), Catherine P Barry (17553288), Jane M Turbov (17553294), Larry G Thaete (17553300), Sharon Stack (17332237), Gustavo C Rodriguez (17553291), Jean A Hurteau (17553297)   +6 more
core   +1 more source

Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong, Sarah Hillman, Sharon Dixon, Anupa Shah, Radha Venkatakrishnan, Jeremy W. Tomlinson   +5 more
wiley   +1 more source

Indications and Efficacy of Progestogen‐Monotherapy as Menopause Hormone Therapy: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Menopausal hormone therapy (MHT) remains the most effective treatment for vasomotor symptoms (VMS) and other manifestations of menopause; however, its use is limited in women with contraindications to oestrogen. Progestogen monotherapy, though historically underutilized, represents a viable alternative in this population. This narrative review
Chloe Thomas, Olivia Carere, Lauren Clarfield, Michelle Jacobson   +3 more
wiley   +1 more source

Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception

, 2011
ReviewSynthetic progestins are used by millions of women as contraceptives and in hormone replacement therapy (HRT), although their molecular mechanisms of action are not well understood.
Donita Africander, Verhoog N., Hapgood J.P., Nicolette Verhoog, Janet P. Hapgood, Africander D.   +5 more
core   +1 more source

Sugammadex interference with serum progesterone measurement: an in‐vitro study

Anaesthesia, EarlyView.
Summary Introduction Sugammadex may interfere with serum progesterone immunoassays, potentially rendering measured concentrations and resulting recommendations unreliable. Methods We investigated the effect of a range of sugammadex concentrations on serum progesterone concentrations in samples from pre‐menopausal female volunteers.
Tamblyn Devoy, Theresa Larkin, Miles Allan, Kevin Mantik, Monika McShane, Natalie A. Smith   +5 more
wiley   +1 more source

Administration of mifepristone can induce masculinization and alter the expression of sex-related genes in Takifugu rubripes

Aquaculture Reports
Fugu (Takifugu rubripes) is a commercially important fish in aquaculture in China, Japan, and Korea. Male fugu are highly prized compared to females because the mature testes are regarded as a delicacy, thus all-male populations are preferred in ...
Rui Gao, Hongwei Yan, Huiting Zhou, Mingtao Hu, Yinpeng Ding, Xufang Shen, Jia Wang, Chenqi Wang, Liu Wang, Chen Jiang, Ying Liu, Xiuli Wang, Qi Liu, Pengfei Hu   +13 more
doaj   +1 more source

Elevated cardiovascular risk associated with hormone replacement therapy: A comprehensive analysis of reproductive factors and atherosclerotic cardiovascular disease outcomes in the UK Biobank cohort

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Among 170,250 UK Biobank women (2006–2024), ever HRT use was associated with higher incident ASCVD risk (adjusted HR 1.13, 95% CI 1.08–1.18), largely driven by ischemic stroke. Associations were stronger in women ≤45 years and during perimenopause. Mediation via sex hormones, inflammatory markers, or lipids was minimal (<2%).
Mengchun Wang, Can Zhang, Chunlai Yang, Baosen Meng, Xiaohui Li, Qian Huang, Baibing Mi   +6 more
wiley   +1 more source

Hormonal replacement therapy in postmenopausal women ≥50 years is associated with the incidence of glaucoma: Evidence from 6576 females in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose Hormonal replacement therapy (HRT) in postmenopausal women appears to affect glaucoma risk, but findings are inconsistent. We aimed to explore whether the use of postmenopausal HRT plays a role in glaucoma development in Finland. Methods The main outcome variable was glaucoma incidence measured by initiation of special reimbursement ...
Sirpa Loukovaara, Jari Haukka
wiley   +1 more source