Results 131 to 140 of about 45,344 (333)

Progestins and breast cancer

open access: yesGynecological Endocrinology, 2007
Progestins exert their progestational activity by binding to the progesterone receptor (form A, the most active and form B, the less active) and may also interact with other steroid receptors (androgen, glucocorticoid, mineralocorticoid, estrogen). They can have important effects in other tissues besides the endometrium, including the breast, liver ...
openaire   +3 more sources

The therapeutic role of exercise training during menopause for reducing vascular disease

open access: yesExperimental Physiology, EarlyView.
Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing   +4 more
wiley   +1 more source

Consistency of endothelial function across two consecutive oral contraceptive pill cycles

open access: yesExperimental Physiology, EarlyView.
Abstract Oral contraceptive pills (OCPs), composed of an active pill (AP; synthetic hormone) and a placebo pill (PP; synthetic hormone‐free) phase, might impact endothelial function across the OCP cycle depending on the synthetic hormone composition (type and dose).
Lindsay A. Lew   +5 more
wiley   +1 more source

Sex hormones and hypertension [PDF]

open access: yes, 2017
Gender has an important influence on blood pressure, with premenopausal women having a lower arterial blood pressure than age-matched men. Compared with premenopausal women, postmenopausal women have higher blood pressures, suggesting that ovarian ...
Dubey, Raghvendra K.   +3 more
core  

Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer

open access: yesInternational Journal of Cancer, Volume 157, Issue 3, Page 480-489, 1 August 2025.
What's new? In this prospective study, the authors evaluated the discrimination capacity of 92 cancer‐related proteins as potential early detection biomarkers for endometrial cancer using blood samples from two large‐scale European population cohorts (EPIC and Janus).
Victoria Cooley   +12 more
wiley   +1 more source

Dopochwowe stosowanie progestagenów

open access: yesMenopause Review, 2010
Progesterone is an essential regulator of the normal female reproductive function in the uterus, ovary, mammary gland and brain. It also plays an important role in non reproductive tissues such as the cardiovascular system, bone and central nervous ...
Artur Chełmicki   +2 more
doaj  

Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth

open access: yesThe FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Obesity reduces in vitro fertilization pregnancy success, with significant decreases in the number of retrieved oocytes, mature oocytes, and cleavage embryos. Mevalonic acid rescues potential productive toxicity of the lipid‐lowering drug simvastatin in follicular development.
Fei Mao   +8 more
wiley   +1 more source

Female sexual function and hormonal contraception (review)

open access: yesГинекология, 2013
The article is devoted to one of the most controversial issues in gynecology, namely the influence of hormonal contraception on female sexuality. We conducted the analysis of the literature data that characterized the features of the female sexual ...
N N Stenyaeva, A A Kuzemin
doaj  

Current approaches to diagnosing and preventing endometrial hyperplasia: A review

open access: yesГинекология
The problem of endometrial hyperplasia (EH) has been relevant for many years, primarily due to the association of abnormal endometrial proliferation with uterus malignancies. Endometrial cancer (EC) risk factors are known, with benign EH being one of the
Irina V. Kuznetsova, Elina R. Vedzizheva
doaj   +1 more source

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

open access: yesClinical Pharmacology in Drug Development, Volume 14, Issue 7, Page 493-504, July 2025.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek   +9 more
wiley   +1 more source

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