Results 91 to 100 of about 295,913 (316)

Galectin-3 as a prognostic biomarker for diabetic nephropathy

, 2019
Hossam Hodeib,1 Maha M Hagras,1 Dina Abdelhai,1 Mona M Watany,1 Amal Selim,2 Mohamed A Tawfik,2 Mohamed A Elsebaey,2 Samah A Elshweikh2 1Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Internal Medicine Department, Faculty of ...
Hodeib H, Tawfik MA, Elshweikh SA, Watany MM, Elsebaey MA, Hagras MM, Selim A, Abdelhai D   +7 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries—A Prospective Cohort Study

Biomedicines
Acute brain injuries (ABIs) pose a substantial global burden, demanding effective prognostic indicators for outcomes. This study explores the potential of urinary p75 neurotrophin receptor (p75NTR) concentration as a prognostic biomarker, particularly in
Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Ying Cao, Janek Frantzén, Fredrika Koskimäki, Johannes Falter, Seán B. Lyne, Tomi Rantamäki, Riikka Takala, Jussi P. Posti, Susanna Roine, Jukka Puolitaival, Miro Jänkälä, Sulo Kolehmainen, Melissa Rahi, Jaakko Rinne, Eero Castrén, Janne Koskimäki   +20 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Prognostic prediction of long-term survival in patients with type A aortic dissection undergoing surgical repair: development of a novel prognostic index

BMC Cardiovascular Disorders
Background This study developed and investigated the prognostic significance of a comprehensive biomarker for postoperative type A aortic dissection (TAAD) patients.
Hao Cai, Yue Shao, Zheng-Hao Li, Xuan-Yu Liu, Xiao-Zhao Zhao, Chang-Ying Li, Hao-Yu Ran, Rui-Qin Zhou, Hao-Ming Shi, Sun Shuangling, Chang-Zhu Duan, Qing-Chen Wu, Cheng Zhang   +12 more
doaj   +1 more source

Prognostic nutritional index as a biomarker for identifying coronary artery lesions in Kawasaki disease

Jornal de Pediatria
Objective: To evaluate the Prognostic Nutritional Index as a biomarker for identifying coronary artery lesions in Kawasaki disease. Methods: The clinicopathological and laboratory characteristics of 241 patients with Kawasaki disease were collected from ...
Chao Zhang, Guoshun Mao, Guosheng Hu
doaj   +1 more source

Prognostic Value of Cardiovascular Biomarkers in the Population

JAMA
ImportanceIdentification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.ObjectiveTo evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors.Design, Setting, and ParticipantsIndividual-level ...
Neumann, Johannes Tobias, Twerenbold, Raphael, Weimann, Jessica, Ballantyne, Christie M., Benjamin, Emelia J., Costanzo, Simona, de Lemos, James A., deFilippi, Christopher R., Di Castelnuovo, Augusto, Donfrancesco, Chiara, Dörr, Marcus, Eggers, Kai M., Engström, Gunnar, Felix, Stephan B., Ferrario, Marco M., Gansevoort, Ron T., Giampaoli, Simona, Giedraitis, Vilmantas, Hedberg, Pär, Iacoviello, Licia, Jørgensen, Torben, Kee, Frank, Koenig, Wolfgang, Kuulasmaa, Kari, Lewis, Joshua R., Lorenz, Thiess, Lyngbakken, Magnus N., Magnussen, Christina, Melander, Olle, Nauck, Matthias, Niiranen, Teemu J., Nilsson, Peter M., Olsen, Michael H., Omland, Torbjorn, Oskarsson, Viktor, Palmieri, Luigi, Peters, Anette, Prince, Richard L., Qaderi, Vazhma, Vasan, Ramachandran S., Salomaa, Veikko, Sans, Susana, Smith, J. Gustav, Söderberg, Stefan, Thorand, Barbara, Tonkin, Andrew M., Tunstall-Pedoe, Hugh, Veronesi, Giovanni, Watanabe, Tetsu, Watanabe, Masafumi, Zeiher, Andreas M., Zeller, Tanja, Blankenberg, Stefan, Ojeda, Francisco   +53 more
openaire   +5 more sources

Use of classical and novel biomarkers as prognostic risk factors for localised prostate cancer : a systematic review [PDF]

, 2009
Objectives: To provide an evidence-based perspective on the prognostic value of novel markers in localised prostate cancer and to identify the best prognostic model including the three classical markers and investigate whether models incorporating ...
P Sutcliffe, Clarke, N., Younger, P, Roome, C, Clarke, Noel W., A Wilkinson, Sutcliffe, P., Rogers, G, A Rees, Hummel, S., Sutcliffe, P. (Paul), Staffurth, John Nicholas, J Staffurth, Somerville, M, F Hamdy, Young, T., Hamdy, F., E Simpson, Wilkinson, A., Rees, A. (Angie), Hamdy, Freddie C., Zawada, A, S Hummel, Taylor, Rod S., T Young, Simpson, E. L. (Emma L.), Staffurth, J., Elston, J, N Clarke, Simpson, E., Garside, R, Wilkinson, A. (Anna), Rees, A., Young, T. (Tracey)   +33 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

STAR (stroma-tumor AI risk) assessment: association of AI-derived tumor-stroma proportion with patient survival provides added prognostic value beyond KELIM in epithelial ovarian cancer

BJC Reports
Background There remains a critical need for prognostic biomarkers of treatment response in epithelial ovarian cancer (EOC). The KELIM score, derived from the rate of CA-125 elimination during the first 100 days of treatment, is a clinically available ...
Arpit Aggarwal, Morgann Madill, Mayukhmala Jana, Tilak Pathak, Timothy K. Starr, Boris Winterhoff, Katelyn M. Tessier, Britt K. Erickson, Andrew C. Nelson, Emil Lou, Anant Madabhushi, Martina Bazzaro   +11 more
doaj   +1 more source