Results 101 to 110 of about 409,524 (305)

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study [PDF]

, 2019
BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers.
Brenner, H., Chang-Claude, J., Charoentong, P., Ferber, D., Gaiser, T., Halama, N., Herpel, E., Hoffmeister, M., Jansen, L., Jäger, D., Kather, J. N., Krisam, J., Luedde, T., Marx, A., Reyes-Aldasoro, C. C., Valous, N. A., Weis, C. A., Zörnig, I.   +17 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Prognostic prediction of long-term survival in patients with type A aortic dissection undergoing surgical repair: development of a novel prognostic index

BMC Cardiovascular Disorders
Background This study developed and investigated the prognostic significance of a comprehensive biomarker for postoperative type A aortic dissection (TAAD) patients.
Hao Cai, Yue Shao, Zheng-Hao Li, Xuan-Yu Liu, Xiao-Zhao Zhao, Chang-Ying Li, Hao-Yu Ran, Rui-Qin Zhou, Hao-Ming Shi, Sun Shuangling, Chang-Zhu Duan, Qing-Chen Wu, Cheng Zhang   +12 more
doaj   +1 more source

Brain Plasticity Modulator p75 Neurotrophin Receptor in Human Urine after Different Acute Brain Injuries—A Prospective Cohort Study

Biomedicines
Acute brain injuries (ABIs) pose a substantial global burden, demanding effective prognostic indicators for outcomes. This study explores the potential of urinary p75 neurotrophin receptor (p75NTR) concentration as a prognostic biomarker, particularly in
Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Ying Cao, Janek Frantzén, Fredrika Koskimäki, Johannes Falter, Seán B. Lyne, Tomi Rantamäki, Riikka Takala, Jussi P. Posti, Susanna Roine, Jukka Puolitaival, Miro Jänkälä, Sulo Kolehmainen, Melissa Rahi, Jaakko Rinne, Eero Castrén, Janne Koskimäki   +20 more
doaj   +1 more source

Prognostic Value of Cardiovascular Biomarkers in the Population

JAMA
ImportanceIdentification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies.ObjectiveTo evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors.Design, Setting, and ParticipantsIndividual-level ...
Neumann, Johannes Tobias, Twerenbold, Raphael, Weimann, Jessica, Ballantyne, Christie M., Benjamin, Emelia J., Costanzo, Simona, de Lemos, James A., deFilippi, Christopher R., Di Castelnuovo, Augusto, Donfrancesco, Chiara, Dörr, Marcus, Eggers, Kai M., Engström, Gunnar, Felix, Stephan B., Ferrario, Marco M., Gansevoort, Ron T., Giampaoli, Simona, Giedraitis, Vilmantas, Hedberg, Pär, Iacoviello, Licia, Jørgensen, Torben, Kee, Frank, Koenig, Wolfgang, Kuulasmaa, Kari, Lewis, Joshua R., Lorenz, Thiess, Lyngbakken, Magnus N., Magnussen, Christina, Melander, Olle, Nauck, Matthias, Niiranen, Teemu J., Nilsson, Peter M., Olsen, Michael H., Omland, Torbjorn, Oskarsson, Viktor, Palmieri, Luigi, Peters, Anette, Prince, Richard L., Qaderi, Vazhma, Vasan, Ramachandran S., Salomaa, Veikko, Sans, Susana, Smith, J. Gustav, Söderberg, Stefan, Thorand, Barbara, Tonkin, Andrew M., Tunstall-Pedoe, Hugh, Veronesi, Giovanni, Watanabe, Tetsu, Watanabe, Masafumi, Zeiher, Andreas M., Zeller, Tanja, Blankenberg, Stefan, Ojeda, Francisco   +53 more
openaire   +5 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Prognostic nutritional index as a biomarker for identifying coronary artery lesions in Kawasaki disease

Jornal de Pediatria
Objective: To evaluate the Prognostic Nutritional Index as a biomarker for identifying coronary artery lesions in Kawasaki disease. Methods: The clinicopathological and laboratory characteristics of 241 patients with Kawasaki disease were collected from ...
Chao Zhang, Guoshun Mao, Guosheng Hu
doaj   +1 more source

Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. [PDF]

, 2016
Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for ...
Cao, Cheng-Xi, Fan, Liu-Yin, Kim, Jae Joon, Kim, Kyoung Mee, Kim, Sung, Kim, Yong, Wong, David TW, Xiao, Hua, Yoshizawa, Janice, Zhang, Yan   +9 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source