Results 61 to 70 of about 295,913 (316)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effects of Coronin 2A on prognosis and immune microenvironment in tumor patients: a knowledge map of the novel biomarker via bioinformatics analysis

Discover Oncology
Background Recent studies have highlighted the vital role of CORO2A in tumor proliferation, migration, and metastasis. However, its immunological and prognostic significance across various cancers remains poorly understood.
Minghe Lv, Jingping Yu, Hongwei Zeng, Ruping Zhao   +3 more
doaj   +1 more source

Retrospective analysis of inflammatory biomarkers and prognosis in non-small cell lung cancer without adenocarcinoma in situ

Frontiers in Genetics
BackgroundInflammatory biomarkers have shown prognostic value in Non-Small Cell Lung Cancer (NSCLC), but the inclusion of Adenocarcinoma In Situ (AIS) cases in previous studies may introduce bias.
Qing Zhao, Songping Cui, Bin Hu, Shuo Chen   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Epigenomic biomarkers insights in PBMCs for prognostic assessment of ECMO-treated cardiogenic shock patients

Clinical Epigenetics
Objective As the global use of extracorporeal membrane oxygenation (ECMO) treatment increases, survival rates have not correspondingly improved, emphasizing the need for refined patient selection to optimize resource allocation.
Yi-Jing Hsiao, Su-Chien Chiang, Chih-Hsien Wang, Nai-Hsin Chi, Hsi-Yu Yu, Tsai-Hsia Hong, Hsuan-Yu Chen, Chien-Yu Lin, Shuenn-Wen Kuo, Kang-Yi Su, Wen-Je Ko, Li-Ming Hsu, Chih-An Lin, Chiou-Ling Cheng, Yan-Ming Chen, Yih-Sharng Chen, Sung-Liang Yu   +16 more
doaj   +1 more source

Can serum progranulin level be used as a prognostic biomarker in non-small cell lung cancer?

Monaldi Archives for Chest Disease, 2022
Progranulin has been considered to be a poor prognostic biomarker for some types of malignancies. However, the clinical significance of serum progranulin level and the prognostic value are still not explored in advanced stages of lung cancer.
Nevin Taci Hoca, Ebru Ünsal, Koza Murat, Arzu Ertürk, Nermin Çapan   +4 more
doaj   +1 more source

Development and evaluation of statistical approaches in proteomic biomarker discovery [PDF]

, 2011
A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.
Patel, Amit
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Prognostic value of pretreatment prognostic nutritional index in non-small cell lung cancer: A systematic review and meta-analysis

The International Journal of Biological Markers, 2018
Background: The pretreatment prognostic nutritional index has been considered a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC), but this remains controversial.
Yuanyuan Hu, Jie Shen, RuiKe Liu, ZhiMei Feng, ChangNing Zhang, Li Ling, LiBo Chen   +6 more
doaj   +1 more source

Expression of Concern: T‐LAK cell‐originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma

Molecular Oncology, 2021
T‐lymphokine‐activated killer (T‐LAK) cell‐originated protein kinase (TOPK) is an emerging target with critical roles in various cancers; however, its expression and function in osteosarcoma remain unexplored.
Pichaya Thanindratarn, Ran Wei, Dylan C. Dean, Arun Singh, Noah Federman, Scott D. Nelson, Francis J. Hornicek, Zhenfeng Duan   +7 more
doaj   +1 more source