Results 241 to 250 of about 866,858 (352)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Construction of a hepatocellular carcinoma prognostic model based on the long non-coding RNA RHPN1-AS1. [PDF]

Discov Oncol
Li X, Li Y, Luan X, Leng C, Li X, Sun X, Tian J, Song J, Guo J, Qiu W.   +9 more
europepmc   +1 more source

Predictive Models Aid Prognostication

JACC: Advances
Ana C. Alba, Tayler A. Buchan, Brigitte Mueller, Stephanie Poon, Susanna Mak, Abdul Al-Hesayen, Mustafa Toma, Shelley Zieroth, Kim Anderson, Catherine Demers, Amin Faizan, Liane Porepa, Sharon Chih, Nadia Giannetti, Valeria Rac, Heather J. Ross, Gordon H. Guyatt   +16 more
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

New Gene Signature-Based Prognostic Model for Patients With VEGF-Overexpressing Esophageal Squamous Cell Carcinoma. [PDF]

Biomed Res Int
Li Y, Wang R, Wang H, Li T, Zhang CL, Dong S, Zhang B.   +6 more
europepmc   +1 more source

Prognostic Factors for Patients with Clinical Stage I Melanoma of Intermediate Thickness (1.51–3.99 mm)* A Conceptual Model for Tumor Growth and Metastasis

, 1982
Calvin L. Day, Martín C. Mihm, Robert Lew, Matthew N. Harris, Alfred W. Kopf, Thomas B. Fitzpatrick, Terence J. Harrist, Frederick M. Golomb, Allen H. Postel, Patrick Hennessey, Stephen L. Gumport, John W. Raker, Ronald A. Malt, A. Benedict Cosimi, William C. Wood, Daniel F. Roses, Fred Gorstein, Darrell S. Rigel, Robert J. Friedman, Medwin M. Mintzis, Arthur J. Sober   +20 more
openalex   +2 more sources

The PFI-index according to Aasen for prognosis and course of polytraumatized patients [PDF]

, 1988
Baumgartner, I., Duswald, Karl-Heimo, Jochum, Marianne, Nast-Kolb, Dieter, Redl, H., Schlag, G., Schweiberer, Leonhard, Waydhas, Christian   +7 more
core  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Dihydromyricetin Remodels the Tumor Immune Microenvironment in Hepatocellular Carcinoma: Development and Validation of a Prognostic Model. [PDF]

Curr Issues Mol Biol
Xu Y, Gu C, Li W, Lan F, Mao J, Tan X, Li P.   +6 more
europepmc   +1 more source