Results 221 to 230 of about 14,715,516 (253)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Development and Validation of a Prognostic Model for Cervical Cancer Based on <i>Chlamydia trachomatis</i>-Associated Transcriptional Signatures. [PDF]

Int J Womens Health
Wang M, Xiong S, Qiu X, Hu Z, Xie L, Zhao H, You C.   +6 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Establishment and evaluation of a prognostic model for sodium overload necrosis in acute myeloid leukemia. [PDF]

Transl Cancer Res
Xie K, Wei J.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Development and validation of a 5mC-based prognostic model for lung adenocarcinoma survival. [PDF]

Cell Rep Med
Wu Y, Jiao Z, Xue J, Zheng X, Huang Z, Wang D, Chen P, Wang T, Chen JQ, Liang N, Tang Y, Wang Q, Chen Q.   +12 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A qEEG-based prognostic model for cognitive impairment after ischemic stroke: Development and internal validation. [PDF]

IBRO Neurosci Rep
Nguyen VT, Quach THT, Do H, Duong KT, Bui KN, Ha H, Pham AG, Tran TC.   +7 more
europepmc   +1 more source

Construction and exploratory validation of a digital pathology prognostic model for stage II-III colorectal cancer based on contrastive learning and attention mechanisms. [PDF]

Front Oncol
Lu Y, Qu Z, Sun C, Li B, Bai X, Zhao Q, Zhang W, Zhao Y, Cao W, Zhou X.   +9 more
europepmc   +1 more source

A two-gene prognostic model for lung adenocarcinoma using summary-data-based Mendelian randomization analysis and Cox proportional hazards regression. [PDF]

Future Sci OA
Xu J, Liu X, Lu Z, Wu X, Yu X, Wang S.
europepmc   +1 more source