Results 21 to 30 of about 866,709 (207)

A signature-based classification of lung adenocarcinoma that stratifies tumor immunity

open access: yesFrontiers in Oncology, 2023
BackgroundImmune-related subgroup classification in immune checkpoint blockade (ICB) therapy is largely inconclusive in lung adenocarcinoma (LUAD).Materials and methodsFirst, the single-sample Gene Set Enrichment Analysis (ssGSEA) and K-means algorithms ...
Xun Zhang   +5 more
doaj   +1 more source

A glycolysis-related gene signatures in diffuse large B-Cell lymphoma predicts prognosis and tumor immune microenvironment

open access: yesFrontiers in Cell and Developmental Biology, 2023
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma which that highly aggressive and heterogeneous. Glycolysis has been implicated in the regulation of tumor microenvironment (TME) and development.
Yingying Cui   +4 more
doaj   +1 more source

The age-adjusted international prognostic index 2 (A-FLIPI2) for elderly patients with follicular lymphoma

open access: yesHeliyon
Follicular lymphoma (FL) is a common B-cell lymphoma and typically affects the elderly population. It is urgently required to enhance our comprehension of disease-specific outcomes in elderly FL patients and identify a reliable predictive indicator to ...
Jiesong Wang   +13 more
doaj   +1 more source

A Bayesian adaptive marker‐stratified design for molecularly targeted agents with customized hierarchical modeling [PDF]

open access: yes, 2019
It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect ...
Cao, Sha   +4 more
core   +3 more sources

Progression of disease within 24 months (POD24) in multiple myeloma implicates poor prognosis and limitations of current prediction models for POD24

open access: yesScientific Reports
Multiple myeloma (MM) is a common hematological malignancy, and its prognostic factors have been extensively studied. Progression of disease within 24 months (POD24) suggests a poor prognosis in many malignancies, but is rarely mentioned in MM.
Yongqin Cao   +5 more
doaj   +1 more source

Distinct clinico-genomic factors drive outcomes in patients with myelofibrosis and disease-related anemia

open access: yesFrontiers in Hematology
BackgroundDisease related anemia in myelofibrosis (MF) is common and prognostically detrimental. Anemia in MF poses a therapeutic challenge as it contributes to poor quality of life and often interferes with JAK inhibitor therapy.
Somedeb Ball   +11 more
doaj   +1 more source

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease [PDF]

open access: yes, 2014
© 2014 John Wiley & Sons Ltd. Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally ...
Allan, James M.   +14 more
core   +1 more source

Establish immune-related gene prognostic index for esophageal cancer

open access: yesFrontiers in Genetics, 2022
Background: Esophageal cancer is a tumor type with high invasiveness and low prognosis. As immunotherapy has been shown to improve the prognosis of esophageal cancer patients, we were interested in the establishment of an immune-associated gene ...
Caiyu Guo   +6 more
doaj   +1 more source

A Similarity-Based Prognostics Approach for Remaining Useful Life Prediction [PDF]

open access: yes, 2014
Physics-based and data-driven models are the two major prognostic approaches in the literature with their own advantages and disadvantages. This paper presents a similarity-based data-driven prognostic methodology and efficiency analysis study on ...
Camci, Faith   +2 more
core   +1 more source

Prognostic value of lymph node ratio and extramural vascular invasion on survival for patients undergoing curative colon cancer resection [PDF]

open access: yes, 2015
There was no study funding. We are grateful to Tony Rafferty (Tailored Information for the People of Scotland, TIPs) for providing survival data.Peer reviewedPublisher ...
A Bhangu   +31 more
core   +2 more sources

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