Results 41 to 50 of about 514,457 (264)

Prognosis of cholangiocarcinoma patients based on multiple patterns of programmed cell death, integrated analysis of the immune microenvironment and drug sensitivity

Frontiers in Genetics
BackgroundCholangiocarcinoma (CHOL) is a highly malignant bile duct cancer with a poor prognosis and rising incidence. Programmed cell death (PCD) plays a crucial role in cancer biology, influencing tumor immunity and treatment response.
Yupeng Xu, Yupeng Xu, Jian Sun, Xin Yan, Zhenliao Mao, Yiming Chen   +5 more
doaj   +1 more source

Development of a 3 RNA Binding Protein Signature for Predicting Prognosis and Treatment Response for Glioblastoma Multiforme

Frontiers in Genetics, 2021
Purpose: Glioblastoma multiforme (GBM) is the most widely occurring brain malignancy. It is modulated by a variety of genes, and patients with GBM have a low survival ratio and an unsatisfactory treatment effect.
Ruohan Sun, Yujun Pan, Long Mu, Yaguang Ma, Hong Shen, Yu Long   +5 more
doaj   +1 more source

Statistical considerations on prognostic models for glioma [PDF]

Neuro-Oncology, 2015
Given the lack of beneficial treatments in glioma, there is a need for prognostic models for therapeutic decision making and life planning. Recently several studies defining subtypes of glioma have been published. Here, we review the statistical considerations of how to build and validate prognostic models, explain the models presented in the current ...
Molinaro, Annette M, Wrensch, Margaret R, Jenkins, Robert B, Eckel-Passow, Jeanette E   +3 more
openaire   +4 more sources

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

External validation of the Oncotype DX breast cancer recurrence score nomogram and development and validation of a novel machine learning-based model to predict postoperative overall survival and guide adjuvant chemotherapy in ER positive, Her-2 negative breast cancer patients: a retrospective cohort study

Frontiers in Oncology
BackgroundThis study aims to externally validate the performance of the Oncotype DX (ODX) breast cancer (BC) recurrence score nomogram in predicting adjuvant chemotherapy (ACT) for BC after surgery and subsequently develop a machine learning-based model ...
Dongdong Wang, Xinfeng Wang, Xin Yang
doaj   +1 more source

Clustering analysis and prognostic model based on PI3K/AKT-related genes in pancreatic cancer

Frontiers in Oncology, 2023
BackgroundPancreatic cancer is one of most aggressive malignancies with a dismal prognosis. Activation of PI3K/AKT signaling is instrumental in pancreatic cancer tumorigenesis.
Xiangying Deng, Xiangying Deng, Xu He, Xu He, Xu He, Zehua Yang, Jing Huang, Lin Zhao, Min Wen, Min Wen, Xiyuan Hu, Zizheng Zou, Zizheng Zou, Zizheng Zou   +13 more
doaj   +1 more source

Ironic Medications: A Narrative‐Based Psycho‐Educational Intervention to Explore Patient–Provider Communication in Adolescents With Haematological Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with haematological malignancies face significant emotional and relational challenges, often accompanied by difficulties in communicating their needs within the healthcare context. To address these issues, a narrative‐based psycho‐educational intervention based on the creation and prescription of Ironic Medications was ...
Marta Stoppa, Elena Pagani Bagliacca, Selena Russo, Giulia Rampoldi, Maria Grazia Strepparava, Adriana Cristina Balduzzi, Andrea Biondi, Marco Spinelli   +7 more
wiley   +1 more source

Construction and validation of a prognostic model based on cuproptosis-related genes in patients with multiple myeloma

陆军军医大学学报
Objective‍　‍To explore the potential cuproptosis-related genes (CRGs) in patients with multiple myeloma (MM) and develop a prognostic model for improving prognosis and revealing features of the MM immune microenvironment.
KANG Zhongmin, KANG Zhongmin, LI Licheng
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla, Sean Carter, Andrew Wood, Sandra Staffieri, Andrew Dodgshun, David D. Eisenstat, Michael Sullivan   +6 more
wiley   +1 more source

Prediction of 5-year postoperative survival and analysis of key prognostic factors in stage III colorectal cancer patients using novel machine learning algorithms

Frontiers in Oncology
ObjectiveThis study explores the predictive value of clinical and socio-demographic characteristics for postoperative survival in stage III colorectal cancer (CRC) patients and develops a 5-year postoperative survival prediction model using machine ...
Wei Zhang, Yan Li, Jinghan Jia, Yuhang Yang, Yuyuan Hu, Yanhong Wang, Jinxi Wang   +6 more
doaj   +1 more source