Results 51 to 60 of about 863,398 (307)

Integrated single-cell and transcriptome sequencing to construct a prognostic model of M2 macrophage-related genes in prostate cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban
ObjectiveTo explore the prognostic value of M2 macrophage-related genes in prostate cancer (PCa), aiming to predict tumor prognosis more accurately and enable personalized treatment.Methods·RNA sequencing (RNA-seq) data of PCa were downloaded from The ...
TANG Kairan, FENG Chengling, HAN Bangmin
doaj   +1 more source

Comprehensive Characterization of RNA Processing Factors in Gastric Cancer Identifies a Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses

Frontiers in Immunology, 2021
RNA processing converts primary transcript RNA into mature RNA. Altered RNA processing drives tumor initiation and maintenance, and may generate novel therapeutic opportunities.
Shenghan Lou, Fanzheng Meng, Xin Yin, Yao Zhang, Bangling Han, Yingwei Xue   +5 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

PAICS-Driven Purine Biosynthesis and Its Prognostic Implications in Lung Adenocarcinoma: A Novel Risk Stratification Model and Therapeutic Insights

Current Issues in Molecular Biology
Background: Lung adenocarcinoma is the most common NSCLC and is associated with metabolic dysregulation. Purine biosynthesis, regulated by PAICS, plays a key role in tumor progression and therapy resistance.
Jinhui Liu, Qi-An Chen, Yannan Yang, Lin Zhang, Weihao Lin, Yuheng Hong, Yibo Gao   +6 more
doaj   +1 more source

A Novel Ferroptosis-Related Gene Signature Predicts Recurrence in Patients With Pancreatic Ductal Adenocarcinoma

Frontiers in Molecular Biosciences, 2021
Background: Recurrence after surgery is largely responsible for the extremely poor outcomes for patients with pancreatic ductal adenocarcinoma (PDAC).
Zengyu Feng, Zengyu Feng, Zengyu Feng, Peng Chen, Kexian Li, Kexian Li, Jianyao Lou, Yulian Wu, Tao Li, Chenghong Peng, Chenghong Peng   +10 more
doaj   +1 more source

Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma. [PDF]

, 2014
Background. Extraskeletal osteosarcoma (ESOS) is a rare subtype of osteosarcoma. We investigated patient characteristics, overall survival, and prognostic factors in ESOS. Methods.
Boscardin, W John, DuBois, Steven G, Goldsby, Robert, Matthay, Katherine K, Thampi, Sheila   +4 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Prognosis of cholangiocarcinoma patients based on multiple patterns of programmed cell death, integrated analysis of the immune microenvironment and drug sensitivity

Frontiers in Genetics
BackgroundCholangiocarcinoma (CHOL) is a highly malignant bile duct cancer with a poor prognosis and rising incidence. Programmed cell death (PCD) plays a crucial role in cancer biology, influencing tumor immunity and treatment response.
Yupeng Xu, Yupeng Xu, Jian Sun, Xin Yan, Zhenliao Mao, Yiming Chen   +5 more
doaj   +1 more source

Development of a 3 RNA Binding Protein Signature for Predicting Prognosis and Treatment Response for Glioblastoma Multiforme

Frontiers in Genetics, 2021
Purpose: Glioblastoma multiforme (GBM) is the most widely occurring brain malignancy. It is modulated by a variety of genes, and patients with GBM have a low survival ratio and an unsatisfactory treatment effect.
Ruohan Sun, Yujun Pan, Long Mu, Yaguang Ma, Hong Shen, Yu Long   +5 more
doaj   +1 more source

Validating a prognostic model [PDF]

Cancer, 2006
H upertan et al. have done a nice analysis of the accuracy of a previously published nomogram when applied to an external dataset. The authors used a sample of 565 men who were treated at a single institution in France. They found that the performance of the nomogram, as measured by the concordance index (similar to the area under a receiver operating ...
openaire   +1 more source