Results 71 to 80 of about 561,995 (314)

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Prediction of 5-year postoperative survival and analysis of key prognostic factors in stage III colorectal cancer patients using novel machine learning algorithms

Frontiers in Oncology
ObjectiveThis study explores the predictive value of clinical and socio-demographic characteristics for postoperative survival in stage III colorectal cancer (CRC) patients and develops a 5-year postoperative survival prediction model using machine ...
Wei Zhang, Yan Li, Jinghan Jia, Yuhang Yang, Yuyuan Hu, Yanhong Wang, Jinxi Wang   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Prognostic clinical and biological markers for amyotrophic lateral sclerosis disease progression: validation and implications for clinical trial design and analysis [PDF]

Background With increasing recognition of the value of incorporating prognostic markers into amyotrophic lateral sclerosis (ALS) trial design and analysis plans, there is a pressing need to understand which among the prevailing clinical and biochemical ...
Granit, Volkan, Rogers, Mary-Louise, Shepheard, Stephanie, Rademakers, Rosa, McHutchison, Caroline A, Hornstein, Eran, Renfrey, Danielle, Statland, Jeffrey M, Cohen, Yahel, Magen, Iddo, Benatar, Michael, Macklin, Eric A, Malaspina, Andrea, Heckmann, Jeannine M, Lombardi, Vittoria   +14 more
core   +1 more source

Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease [PDF]

, 2010
Background: Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events ...
Adam D Timmis, Kate S L McAllister, Fitzpatrick Natalie K., J. Damant (7608818), Stephen Palmer, McAllister, Kate, Aroon D Hingorani, A. D. Timmis (7608830), Hingorani, AD, Chen Ruoling, A. D. Hingorani (7602500), Damant Jacqueline, Fitzpatrick, NK, Timmis Adam D., Keith R. Abrams, J. C. Kaski (7608827), Palmer, S, Fitzpatrick, Natalie K., Chen, Ruoling, Abrams, Keith R, Harry Hemingway, Timmis, Adam D, Philipson, P, Santiago Moreno, Natalie K. Fitzpatrick, Palmer, Stephen, Turnbull, Fiona Mary, McAllister, Kate S L, Damant, J, Timmis, Adam D., K. S. L. McAllister (7608824), Moreno, Santiago, Kaski, JC, Philipson Peter, Hingorani, Aroon D, Hemingway Harry, Adam D. Timmis, Fitzpatrick, Natalie K, Abrams Keith R., Keith R. Abrams (7579436), Shipley, Martin, Palmer Stephen, Hemingway, Harry, Shipley Martin, Abrams, Keith R., Chen, R, H. Hemingway (7608809), McAllister, KSL, Shipley, M, Timmis, AD, Moreno Santiago, Natalie K Fitzpatrick, Hingorani Aroon D., Damant, Jacqueline, Juan Carlos Kaski, Fitzpatrick, Natalie, Philipson, Peter, McAllister, KS, N. K. Fitzpatrick (7608815), Kaski Juan Carlos, P. Philipson (7608812), Abrams, Keith, Kate S. L. McAllister, S. Palmer (3693193), Martin Shipley, Peter Philipson, Jacqueline Damant, M. Shipley (7608821), McAllister Kate S. L., Santiago Moreno (90184), Chen, RL, Moreno, S, Mcallister, Katherine, Abrams, KR, R. Chen (576618), Hingorani, Aroon D., Kaski, Juan Carlos, Keith R Abrams, Hemingway, H, Timmis, Adam, Aroon D. Hingorani, Ruoling Chen, Philipson, Pete, Hingorani, Aroon   +83 more
core   +1 more source

Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling

Frontiers in Immunology
IntroductionOsteosarcoma (OS) is the most common primary bone malignancy, predominantly affecting children and adolescents. Current treatment approaches have limited efficacy, with a 5-year survival rate of approximately 60%.
Jiaming Zhang, Wei Wang
doaj   +1 more source

Integrating Genomics Into Prognostic Models for AML [PDF]

Seminars in Hematology, 2014
The use of genomic profiling in acute myeloid leukemia (AML) has led to an improved understanding of disease pathogenesis. Genomic profiling has given rise to fundamental observations about the biology of AML and has served to better define clinical outcomes for patients based on somatic mutational status.
Matias, Sanchez, Ross L, Levine, Raajit, Rampal   +2 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis

Frontiers in Immunology
Sepsis is a life-threatening condition caused by a dysregulated host response to infection and is one of the leading causes of morbidity and mortality worldwide.
Chunyang Li, Haiyan Xue, Haiyan Xue, Lihe Chen, Fengxue Zhu, Jie Li   +5 more
doaj   +1 more source

Validating a prognostic model [PDF]

Cancer, 2006
H upertan et al. have done a nice analysis of the accuracy of a previously published nomogram when applied to an external dataset. The authors used a sample of 565 men who were treated at a single institution in France. They found that the performance of the nomogram, as measured by the concordance index (similar to the area under a receiver operating ...
openaire   +1 more source