Results 91 to 100 of about 561,995 (314)

Prognostic indicators of early and late death in children admitted to district hospital in Kenya: cohort study

, 2003
OBJECTIVES: To identify clinical indicators of immediate, early, and late mortality in children at admission to a sub-Saharan district hospital and to develop prognostic scores. DESIGN: Prospective cohort study.
Osier, FH, Ross, A, Marsh, K, Shebbe, M, Berkley, James A, Berkley, JA, Mwangi, I, Osier, F.H.A., Lowe, BS, Mohammed, M, Marsh, Kevin, Newton, Charles R.J.C., Newton, CR, Lowe, B.S.   +13 more
core   +1 more source

Inflammation-nutrition biomarker model for survival prediction in lung cancer patients with concurrent tuberculosis

Frontiers in Molecular Biosciences
ObjectivesTo explore the prognostic value of eight inflammation-nutrition biomarkers in patients with lung cancer and tuberculosis as no multidimensional prognostic models for this comorbid population are available currently.MethodologyA retrospective ...
Hongqi Zhou, Zihao Zhao, Jinhai Wang, Weiyun Jin, Bensong Xian, Lindi Li, XiangWen Nie, WeiWei Wu, Ran Chen, QiZhen Xie, HaiXia Wu, WeiWei Jiang, Min Tang, YuXin Li   +13 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Building Cox-Type Structured Hazard Regression Models with Time-Varying Effects [PDF]

, 2008
In recent years, flexible hazard regression models based on penalised splines have been developed that allow us to extend the classical Cox-model via the inclusion of time-varying and nonparametric effects.
Küchenhoff, Helmut, Kneib, Thomas, Hartl, Wolfgang, Hofner, Benjamin   +3 more
core   +1 more source

The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights

Frontiers in Immunology
BackgroundRadiotherapy elicits immune activation, thereby synergistically enhancing systemic tumor control when combined with immunotherapy. Glutaminase (GLS), a key enzyme for glutamine metabolism, has been found to regulate glutamine availability ...
Peicheng Jiang, Zhifeng Jiang, Su Li, Su Li, Ye-Xiong Li, Yuqiong Chen, Xinyan Li   +6 more
doaj   +1 more source

Interpretable prognostics with concept bottleneck models

Information Fusion
Under ...
Florent Forest, Katharina Rombach, Olga Fink   +2 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Prognostic factors for malignant mesothelioma in 142 patients : validation of CALGB and EORTC prognostic scoring systems

, 2000
*This article is free to read on the publisher's website*\ud \ud Background \ud \ud The incidence of malignant mesothelioma is increasing. There is the perception that survival is worse in the UK than in other countries.
Leverment, JN., O'Byrne, K.J., Waller, D.A., Abrams, K.R., Edwards, J.G., Spyt, T.J.   +5 more
core   +1 more source

The impact of loco-regional recurrences on metastatic progression in early-stage breast cancer: a multistate model [PDF]

, 2009
To study whether the effects of prognostic factors associated with the occurrence of distant metastases (DM) at primary diagnosis change after the incidence of loco-regional recurrences (LRR) among women treated for invasive stage I or II breast cancer ...
de Bock, G. H., van de Velde, C. J., Hage, J. A., Putter, H., Bartelink, H., de Bock, G.H., Velde, C. J., de Bock, G. H.; id_orcid, van de Velde, C.J., van der Hage, J.A., van der Hage, J. A., Bock, G. H., Bonnema, J.   +12 more
core   +1 more source

The Impact of Tertiary Lymphoid Structures on Tumor Prognosis and the Immune Microenvironment in Colorectal Cancer

Biomedicines
Background: Colorectal cancer (CRC) ranks as the third most common cancer worldwide. Tertiary lymphoid structures (TLSs), organized immune cell aggregates in non-lymphoid tissues, are linked to chronic inflammation and tumorigenesis. However, the precise
Leyi Zhao, Lingze Xi, Yani Liu, Guoliang Wang, Mingtong Zong, Peng Xue, Shijie Zhu   +6 more
doaj   +1 more source