Results 101 to 110 of about 561,995 (314)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy.

, 2010
Purpose To develop a prognostic model in patients with germ cell tumors (GCT) who experience treatment failure with cisplatin-based first-line chemotherapy.
Beyer J, Kollmannsberger CK., Margolin KA, Lotz JP, Einhorn LH, Kollmannsberger CK, Lorch A, Germa Lluch JR, International Prognostic Factors Study Group, De Giorgi U, Powles T, Bascoul-Mollevi C, Kramar A, Fléchon A, Lluch JRG, Necchi A, Massard C   +16 more
core   +1 more source

Modeling Prognostic Factors in Resectable Pancreatic Adenocarcinomas [PDF]

, 2009
Background: The accurate prognosis for patients with resectable pancreatic adenocarcinomas requires the incorporation of more factors than those included in AJCC TNM system.
Gunnar Hartvigsen, Anagnostou, Valsamo K., Botsis, Taxiarchis, Hripcsak, George, Chunhua Weng, Taxiarchis Botsis, Valsamo K. Anagnostou, Hartvigsen, Gunnar, George Hripcsak, Weng, Chunhua   +9 more
core   +1 more source

Programmed cell death-related prognostic genes mediate dysregulation of the immune microenvironment in triple-negative breast cancer

Frontiers in Immunology
BackgroundProgrammed Cell death (PCD) encompasses a spectrum of genetically regulated cell death processes and plays a double-edged sword role in neoplastic progression and therapeutic resistance of Triple-Negative Breast Cancer(TNBC)through the tumor ...
Xiaowen Ma, Hui Shan, Zhao Chen, Rongzi Shao, Ning Han   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hypoxia-associated genes as predictors of outcomes in gastric cancer: a genomic approach

Frontiers in Immunology
ObjectiveTo investigate the effects of hypoxia-related genes in stomach adenocarcinoma (STAD) and construct an excellent prognostic model.MethodsRNA expression data and clinical details were retrieved from the TCGA and GEO database dataset.
Shuo Yang, Shuo Yang, Yuhao Jiang, Zhonghua Yang, Zhonghua Yang   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Royal Free Hospital score: a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit. Comparison with current models and CLIF-SOFA score

, 2014
Prognosis for patients with cirrhosis admitted to intensive care unit (ICU) is poor. ICU prognostic models are more accurate than liver-specific models.
Cholongitas, E, Agarwal, B, Cheung, M, Burroughs, AK, Pieri, G, Theocharidou, E, Mohammad, AO   +6 more
core  

Developing and validating a predictive model for stroke progression [PDF]

, 2011
<p><b>Background:</b> Progression is believed to be a common and important complication in acute stroke, and has been associated with increased mortality and morbidity.
O. Wu, Gilmour, H., L.E. Craig, Langhorne, P., M. Barber, P. Langhorne, Craig, L.E., H. Gilmour, Barber, M., Wu, Olivia   +9 more
core   +1 more source

Identification of DAP3 as candidate prognosis marker and potential therapeutic target for hepatocellular carcinoma

Frontiers in Immunology
BackgroundAmong malignant tumors, hepatocellular carcinoma (HCC) is both prevalent and highly lethal. Most patients with advanced-stage liver cancer have a poor prognosis.
Liu-Xia Yuan, Zhi-Qiang Yue, Qin-Rong Ma, Peng Zhang, Feng Xiao, Lin Chen   +5 more
doaj   +1 more source