Results 91 to 100 of about 842,511 (301)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A comparison of landmark methods and time-dependent ROC methods to evaluate the time-varying performance of prognostic markers for survival outcomes

Diagnostic and Prognostic Research, 2019
Background Prognostic markers use an individual’s characteristics at a given time to predict future disease events, with the ultimate goal of guiding medical decision-making.
Aasthaa Bansal, Patrick J. Heagerty
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Library research in the future: A prognostication

College & Research Libraries News, 1989
Library research in the future: A ...
openaire   +2 more sources

Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran [PDF]

, 2009
Background: while there has been much research regarding risk factors and prognostic factors for breast cancer in general, research specific to Iran is sparse.
Talei, Abdolrasoul, Rezaianzadeh, Abbas, Daniel Reidpath, Reidpath Daniel, Reidpath, D, Peacock, J, Hosseini, SV, Talei Abdolrasoul, Hosseini, Seyed Vahid, Hosseini, Seyed Vahid, Seyed Hosseini, Rezaianzadeh Abbas, Davood Mehrabani, Talei, A, Janet Peacock, Hoseini Seyed, Mehrabani, D, Mehrabani Davood, Rezaianzadeh, A, Peacock, Janet, Hosseini, S.V, Peacock Janet, Seyed Vahid Hosseini, Peacock, J.L, Mehrabani, Davood, Reidpath, Daniel, Abdolrasoul Talei, Reidpath, DD, Abbas Rezaianzadeh   +28 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The index of prediction accuracy: an intuitive measure useful for evaluating risk prediction models

Diagnostic and Prognostic Research, 2018
Background Many measures of prediction accuracy have been developed. However, the most popular ones in typical medical outcome prediction settings require additional investigation of calibration.
Michael W. Kattan, Thomas A. Gerds
doaj   +1 more source

Harnessing repeated measurements of predictor variables for clinical risk prediction: a review of existing methods

Diagnostic and Prognostic Research, 2020
Background Clinical prediction models (CPMs) predict the risk of health outcomes for individual patients. The majority of existing CPMs only harness cross-sectional patient information.
Lucy M. Bull, Mark Lunt, Glen P. Martin, Kimme Hyrich, Jamie C. Sergeant   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source