Results 51 to 60 of about 842,511 (301)

Sample size determination for point-of-care COVID-19 diagnostic tests: a Bayesian approach

Diagnostic and Prognostic Research, 2023
Background In a pandemic setting, it is critical to evaluate and deploy accurate diagnostic tests rapidly. This relies heavily on the sample size chosen to assess the test accuracy (e.g.
S. Faye Williamson, Cameron J. Williams, B. Clare Lendrem, Kevin J. Wilson   +3 more
doaj   +1 more source

Comparison of techniques for handling missing covariate data within prognostic modelling studies: a simulation study [PDF]

, 2010
Background: There is no consensus on the most appropriate approach to handle missing covariate data within prognostic modelling studies. Therefore a simulation study was performed to assess the effects of different missing data techniques on the ...
Holder, Roger, Douglas G Altman, Holder, RL, Royston, Patrick, Royston, P, Marshall, A, Patrick Royston, Holder, Roger L., Altman, DG, Roger L Holder, Altman, Douglas G., Andrea Marshall, Marshall, A. (Andrea)   +12 more
core   +1 more source

The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review

BJA Open
Background: This systematic review describes the prognostic value of postoperative cardiac high-sensitive troponin I and T as risk markers for major adverse cardiac events (MACE) after coronary artery bypass graft (CABG) surgery and their predictive ...
Maaike S.Y. Thio, Peter G. Noordzij, Janice H. Klingenberg, Frieda Renkens, Lisette M. Vernooij, Olaf L. Cremer, Linda M. Posthuma, Thijs C.D. Rettig   +7 more
doaj   +1 more source

Decision curve analysis: confidence intervals and hypothesis testing for net benefit

Diagnostic and Prognostic Research, 2023
Background A number of recent papers have proposed methods to calculate confidence intervals and p values for net benefit used in decision curve analysis. These papers are sparse on the rationale for doing so.
Andrew J. Vickers, Ben Van Claster, Laure Wynants, Ewout W. Steyerberg   +3 more
doaj   +1 more source

The necessary shift from diagnostic to prognostic research [PDF]

BMC Family Practice, 2007
Do doctors really need to establish an etiological diagnosis each time a patient presents? Or might it often be more effective to treat simply on the basis of symptoms and signs alone, relying on research and on our experience of outcomes for patients who presented in similar ways in the past?At a time of increase health care costs especially in ...
Dinant, G, Buntinx, F, Butler, C
openaire   +3 more sources

Modest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis [PDF]

, 2009
Background: P53, egfr and her-2/neu are the most frequently studied molecular biological parameters in epithelial ovarian cancer, but their prognostic impact is still unequivocal.
de Jong, S., de Vries, E.G.E., de Bock, G.H.; id_orcid, Boezen, M., Post, W.J., van der Zee, A.G.J., de Vries, E.G.E.; id_orcid, Crijns, A.P.G., de Jong, S.; id_orcid, de Graeff, P., de Bock, G.H.   +10 more
core   +1 more source

Epigenetics in diagnosis, prognostic assessment and treatment of cancer:An update [PDF]

, 2014
Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and ...
Crook, Tim, Briasoulis, Evangelos, Sim, Van Ren, Hatzimichael, Eleftheria, Lagos, Konstantinos   +4 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer

, 2023
BACKGROUND: We aimed to investigate the effect of hemoglobin/prognostic nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer.
Elif Tuğba Tuncel, Tuncel, Elif Tuğba, Parvizi, Murtaza, Engin Kut, Murtaza Parvizi, Kut, Engin, Mesut Aydın, Kasap, Elmas, Aydın, Mesut, Mesut Aydin, Elmas Kasap   +10 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source