Results 61 to 70 of about 823,140 (217)

Commentary: The Circulatory Effects of Increased Hydrostatic Pressure Due to Immersion and Submersion

Frontiers in Physiology, 2022
Jacques Regnard, Malika Bouhaddi, Olivier Castagna, Olivier Castagna, Laurent Mourot, Laurent Mourot   +5 more
doaj   +1 more source

Editorial: Prognostic research and precision oncology in upper tract urothelial carcinoma-volume II. [PDF]

Front Oncol, 2023
Yang TM, Singla N, Chen CH, Hsieh JT, Yeh HC.   +4 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Developing a Core Outcome Set for Prognostic Research in Palliative Cancer Care: Protocol for a Mixed Methods Study. [PDF]

JMIR Res Protoc, 2023
Spooner C, Vivat B, White N, Stone P.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Prediction models developed using artificial intelligence: similar predictive performances with highly varying predictions for individuals – an illustration in deep vein thrombosis

Diagnostic and Prognostic Research
Objectives The rise in popularity and off-the-shelf availability of machine learning (ML) and AI-based methodology to develop new prediction models provides developers with ample choices to compare and select the best performing model out of many ...
Maerziya Yusufujiang, Constanza L Andaur Navarro, Johanna AA Damen, Toshihiko Takada, Geert-Jan Geersing, Lotty Hooft, Ewoud Schuit, Karel GM Moons, Valentijn MT de Jong, Maarten van Smeden   +9 more
doaj   +1 more source

Editorial: Prognostic Research and Precision Oncology in Upper Tract Urothelial Carcinoma. [PDF]

Front Oncol, 2022
Sheu ZL, Singla N, Chen CH, Hsieh JT, Yeh HC.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Development and internal validation of a prediction model for post-COVID-19 condition 2 years after infection—results of the CORFU study

Diagnostic and Prognostic Research
Background A subset of COVID-19 patients develops post-COVID-19 condition (PCC). This condition results in disability in numerous areas of patients’ lives and a reduced health-related quality of life, with societal impact including work absences and ...
Dorthe Odyl Klein, Nick Wilmes, Sophie F Waardenburg, Gouke J Bonsel, Erwin Birnie, Marieke SJN Wintjens, Stella CM Heemskerk, Emma BNJ Janssen, Chahinda Ghossein-Doha, Michiel C Warlé, Lotte MC Jacobs, Bea Hemmen, Jeanine A Verbunt, Bas CT van Bussel, Susanne van Santen, Bas LJH Kietselaer, Gwyneth Jansen, Folkert W Asselbergs, Marijke Linschoten, Juanita A Haagsma, S.M.J van Kuijk, CAPACITY-COVID Collaborative Consortium   +21 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source