Results 51 to 60 of about 54,878 (125)
Scientific ReportsThis study aimed to investigate the potential of autophagy-related genes (ATGs) as a prognostic signature for HCC and explore their relationships with immune cells and immune checkpoint molecules.
Zhen Ma +3 more
doaj +1 more source
Cancer Cell International, 2021 Background Given that dysregulated metabolism has been recently identified as a hallmark of cancer biology, this study aims to establish and validate a prognostic signature of lung adenocarcinoma (LUAD) based on metabolism-related genes (MRGs).
Zhihao Wang +9 more
doaj +1 more source
No evidence of histology subtype-specific prognostic signatures among lung adenocarcinoma and squamous cell carcinoma patients at early stages [PDF]
arXiv, 2014 Background Non-small cell lung cancer (NSCLC) is the predominant histological type of lung cancer, accounting for up to 85% of cases. Disease stage is commonly used to determine adjuvant treatment eligibility of NSCLC patients, however, it is an imprecise predictor of the prognosis of an individual patient.
arxiv
A simplified convolutional sparse filter for impulsive signature enhancement and its application to the prognostic of rotating machinery [PDF]
arXiv, 2018 Impulsive signature enhancement (ISE) is an important topic in the monitoring of rotating machinery and many different methods have been proposed. Even though, the topic of how to leverage these ISE techniques to improve the data quality in terms of prognostics and health management (PHM) still needs to be investigated.
arxiv
An evaluation of DNA-damage response and cell-cycle pathways for breast cancer classification [PDF]
, 2015 Accurate subtyping or classification of breast cancer is important for ensuring proper treatment of patients and also for understanding the molecular mechanisms driving this disease. While there have been several gene signatures proposed in the literature to classify breast tumours, these signatures show very low overlaps, different classification ...
arxiv +1 more source
Integrating Prior Knowledge Into Prognostic Biomarker Discovery based on Network Structure [PDF]
arXiv, 2012 Background: Predictive, stable and interpretable gene signatures are generally seen as an important step towards a better personalized medicine. During the last decade various methods have been proposed for that purpose. However, one important obstacle for making gene signatures a standard tool in clinics is the typical low reproducibility of these ...
arxiv
Bioinformatic analysis and experimental validation of six cuproptosis-associated genes as a prognostic signature of breast cancer [PDF]
PeerJBackground Breast carcinoma (BRCA) is a life-threatening malignancy in women and shows a poor prognosis. Cuproptosis is a novel mode of cell death but its relationship with BRCA is unclear.
Xiang Chen +9 more
doaj +2 more sources
Increasing stability and interpretability of gene expression signatures [PDF]
arXiv, 2010 Motivation : Molecular signatures for diagnosis or prognosis estimated from large-scale gene expression data often lack robustness and stability, rendering their biological interpretation challenging. Increasing the signature's interpretability and stability across perturbations of a given dataset and, if possible, across datasets, is urgently needed ...
arxiv
Genes and Diseases, 2022 Emerging evidence suggests that peroxisomes play a role in the regulation of tumorigenesis and cancer progression. However, the prognostic value of peroxisome-related genes has been rarely investigated.
Liewang Qiu +4 more
doaj
Cellular Physiology and Biochemistry, 2018 Background/Aims: In the current study, we performed an integrated analysis of genome-wide methylation and gene expression data to find novel prognostic genes for lower-grade gliomas (LGGs).
Wen-Jing Zeng +9 more
doaj +1 more source