Biomarker analyses of clinical outcomes in patients with advanced hepatocellular carcinoma treated with Sorafenib with or without Erlotinib in the SEARCH Trial [PDF]
, 2016 Purpose: Sorafenib is the current standard therapy for advanced HCC, but validated biomarkers predicting clinical outcomes are lacking. This study aimed to identify biomarkers predicting prognosis and/or response to sorafenib, with or without erlotinib,
Evans, T.R. Jeffrey +10 more
core +1 more source
Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction. [PDF]
, 2013 Tumor heterogeneity is a limiting factor in cancer treatment and in the discovery of biomarkers to personalize it. We describe a computational purification tool, ISOpure, to directly address the effects of variable normal tissue contamination in clinical
Boutros, Paul C +5 more
core +2 more sources
Integrative analysis of the colorectal cancer proteome : potential clinical impact [PDF]
, 2016 Peer ...
Alnabulsi, Abdo, Murray, Graeme I.
core +2 more sources
Prognostic relevance of gene-expression signatures
, 2022 Cancer prognosis can be regarded as estimating the risk of future outcomes from multiple variables. In prognostic signatures, these variables represent expressions of genes that are summed up to calculate a risk score. However, it is a natural phenomenon in living systems that the whole is more than the sum of its parts.
Tschodu, Dimitrij +5 more
openaire +2 more sources
Comparison of prognostic gene expression signatures for breast cancer [PDF]
BMC Genomics, 2008 Abstract Background During the last years, several groups have identified prognostic gene expression signatures with apparently similar performances. However, signatures were never compared on an independent population of untreated breast cancer patients, where risk assessment was computed using the original ...
Haibe-Kains, Benjamin +8 more
openaire +5 more sources
Development of an Immune-Related LncRNA Prognostic Signature for Glioma [PDF]
Frontiers in Genetics, 2021 IntroductionGlioma is the most common primary cancer of the central nervous system with dismal prognosis. Long noncoding RNAs (lncRNAs) have been discovered to play key roles in tumorigenesis in various cancers, including glioma. Because of the relevance between immune infiltrating and clinical outcome of glioma, identifying immune-related lncRNAs is ...
Quanwei Zhou +14 more
openaire +4 more sources
Development and validation of an immune gene-set based prognostic signature for soft tissue sarcoma
BMC Cancer, 2021 Background Sarcomas is a group of heterogeneous malignant tumors originated from mesenchymal tissue and different types of sarcomas have disparate outcomes. The present study aims to identify the prognostic value of immune-related genes (IRGs) in sarcoma
Rui Shen +5 more
doaj +1 more source
Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data. [PDF]
, 2014 Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year.
Bainbridge, Matthew N +3 more
core +1 more source
Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma
Cancer Cell International, 2019 Background Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed.
Gao-Min Liu +3 more
doaj +1 more source
Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma
BMC Ophthalmology, 2023 Background To identify an immune-related prognostic signature and find potential therapeutic targets for uveal melanoma. Methods The RNA-sequencing data obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets.
Binghua Yang +4 more
doaj +1 more source