Results 61 to 70 of about 13,873 (186)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Bioinformatic Analysis of the Campylobacter jejuni Type VI Secretion System and Effector Prediction. [PDF]
Front Microbiol, 2021 Robinson L +7 more
europepmc +1 more source
El paper de la dona en el desenvolupament de les zones rurals [PDF]
, 2006 Las mujeres rurales son las principales productoras de alimentos y representan el 60% de la mano de obra agrícola. Sin embargo, sufren una doble marginación por ser mujeres y por ser rurales-, lo que no sólo es una merma de sus derechos, sino un factor ...
Felipe, Isabel de, Zekri, Lina
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
L'emprenedoria femenina i la immigració a Osona. El suport dels serveis municipals [PDF]
, 2012 En la literatura sobre creació d’empreses, les dones empresàries són considerades un reservori de desenvolupament econòmic i un model de gestió empresarial alternatiu. D’altra banda, els immigrants posseeixen un fort esperit emprenedor.
Pérez-Quintana, Anna
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2012 El siguiente documento corresponde a la memoria del proyecto de final de carrera de Ingeniería Informática, que contiene el diseño y la implementación del videojuego Launchageddon. Éste corresponde a un proyecto desarrollado entre tres personas.
Cartes Rosell, Jordi +3 more
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