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WormBook, 2005 Programmed cell death is an integral component of C. elegans development. Genetic studies in C. elegans have led to the identification of more than two dozen genes that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells.
Barbara Conradt, Ding Xue
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Programmed Cell Death in Cystinosis [PDF]
Cells, 2022 Cystinosis is a lethal autosomal recessive disease that has been known clinically for over 100 years. There are now specific treatments including dialysis, renal transplantation and the orphan drug, cysteamine, which greatly improve the duration and quality of patient life, however, the cellular mechanisms responsible for the phenotype are unknown. One
Elizabeth G. Ames, Jess G. Thoene
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Programmed Cell Death in Neurodevelopment [PDF]
Developmental Cell, 2015 Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system development. In the vertebrate peripheral nervous system, PCD is the basis of the neurotrophic theory, whereby cell death results from a surplus of neurons relative to target and competition for neurotrophic factors. In addition to stochastic cell death, PCD can be
Yoshifumi Yamaguchi +2 more
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Apoptosis, 2022 Research on cell death mechanisms gets a lot of attention. This is understandable as it underlies biology in general, as well as the insight in pathological conditions and the development of opportunities for therapeutic intervention. Over the last years a steady rise in the number of scientific reports and in the impact of this literature on the ...
Griffioen, Arjan W. +1 more
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Programmed cell death in the skin
The International Journal of Developmental Biology, 2015 Differently from the other cells of the body, epidermal cells of the skin undergo a specific programmed cell death form named cornification. Many events take part to control this process, which has been described as a terminal differentiation program.
Costanzo, Antonio +5 more
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Apoptosis: Programmed Cell Death [PDF]
Archives of Surgery, 1998 Currently there is much interest and excitement in the understanding of how cells undergo the process of apoptosis or programmed cell death. Understanding how, why, and when cells are instructed to die may provide insight into the aging process, autoimmune syndromes, degenerative diseases, and malignant transformation.
Nai-Kang Kuan, Edward Passaro
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, 2014 Recent studies in Drosophila, Hydra, planarians, zebrafish, mice, indicate that cell death can open paths to regeneration in adult animals. Indeed injury can induce cell death, itself triggering regeneration following an immediate instructive mechanism, whereby the dying cells release signals that induce cellular responses over short and/or long-range ...
Silke Reiter +3 more
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Programmed cell death in protists
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 Programmed cell death in protists does not seem to make sense at first sight. However, apoptotic markers in unicellular organisms have been observed in all but one of the six/eight major groups of eukaryotes suggesting an ancient evolutionary origin of this regulated process.
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Polyamines and programmed cell death [PDF]
Journal of Experimental Botany, 2013 Polyamines (PAs) have been considered as important molecules for survival. However, evidence reinforces that PAs are also implicated, directly or indirectly, in pathways regulating programmed cell death (PCD). Direct correlation of PAs with cell death refers to their association with particular biological processes, and their physical contact with ...
Panagiotis N. Moschou +1 more
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Programmed cell death in aging [PDF]
Ageing Research Reviews, 2015 Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is increasingly implicated in aging and aging-related disease. During aging the cell turnover rate declines for several highly-mitotic tissues. Aging-associated disruptions in systemic and
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