Results 11 to 20 of about 1,266,471 (355)

Mitochondria-associated programmed cell death as a therapeutic target for age-related disease

Experimental and Molecular Medicine, 2023
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate.
Thanh T Nguyen, Shibo Wei, Thu Ha Nguyen, Yunju Jo, Yan Zhang, Wonyoung Park, Karim Gariani, Chang-Myung Oh, Hyeon-ho Kim, Ki-Tae Ha, Kyu-Sang Park, Raekil Park, In-Kyu Lee, M. Shong, R. Houtkooper, D. Ryu   +15 more
semanticscholar   +1 more source

Programmed Cell Death in Cystinosis

Cells, 2022
Cystinosis is a lethal autosomal recessive disease that has been known clinically for over 100 years. There are now specific treatments including dialysis, renal transplantation and the orphan drug, cysteamine, which greatly improve the duration and ...
Elizabeth G. Ames, Jess G. Thoene
doaj   +1 more source

Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

Cell Death and Disease, 2023
Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular proteins.
Zhen Xie, Mengyuan Zhao, Chengxiang Yan, W. Kong, Fei Lan, Narengaowa, Shuxuan Zhao, Qinghu Yang, Zhantao Bai, H. Qing, Junjun Ni   +10 more
semanticscholar   +1 more source

Programmed cell death in cerebellar Purkinje neurons [PDF]

Journal of Integrative Neuroscience, 2022
Apoptosis, autophagy and necrosis are the three main types of programmed cell death. One or more of these types of programmed cell death may take place in neurons leading to their death in various neurodegenerative disorders in humans.
Nour S. Erekat
doaj   +1 more source

Programmed cell death detection methods: a systematic review and a categorical comparison

Apoptosis, 2022
Programmed cell death is considered a key player in a variety of cellular processes that helps to regulate tissue growth, embryogenesis, cell turnover, immune response, and other biological processes.
Sana Kari, K. Subramanian, Ilenia Agata Altomonte, A. Murugesan, O. Yli-Harja, M. Kandhavelu   +5 more
semanticscholar   +1 more source

Programmed cell death and liver diseases

Вестник трансплантологии и искусственных органов, 2022
Cell death represents the most critical pathologic entity in liver disease, which dictates pathologic consequences such as inflammation, fibrosis, and cell transformation.
N. A. Onishchenko, Z. Z. Gonikova, A. O. Nikolskaya, L. A. Kirsanova, V. I. Sevastianov   +4 more
doaj   +1 more source

Insights into N6-methyladenosine and programmed cell death in cancer

Molecular Cancer, 2022
N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a hot research topic in recent years.
L. Liu, Hui Li, Dingyu Hu, Yanyan Wang, Wenjun Shao, Jing Zhong, Shudong Yang, Jing Liu, Ji Zhang   +8 more
semanticscholar   +1 more source

Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Theranostics, 2021
In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated remarkable achievements. However, emerging evidence has shown that chemoresistance is mediated by impairing or bypassing apoptotic cell death.
Sheng-Kai Hsu, Chia-Yang Li, I.-Ling Lin, Wun-Jyun Syue, Yih-Fung Chen, Kai-Chun Cheng, Y. Teng, Yi-Hsiung Lin, Chia-Hung Yen, Chien-Chih Chiu   +9 more
semanticscholar   +1 more source

Programmed cell death in atherosclerosis and vascular calcification

Cell Death and Disease, 2022
The concept of cell death has been expanded beyond apoptosis and necrosis to additional forms, including necroptosis, pyroptosis, autophagy, and ferroptosis.
Min Li, Zhenwei Wang, L. Fang, Shou-Quan Cheng, Xin Wang, Nai-Feng Liu   +5 more
semanticscholar   +1 more source

Regulation of cell death in cancer - possible implications for immunotherapy [PDF]

, 2013
Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape.
Fulda, Simone
core   +2 more sources