Results 11 to 20 of about 1,284,058 (379)
Copper induces cell death by targeting lipoylated TCA cycle proteins
Science, 2022 Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How excess copper induces cell death, however, is unknown.
Peter Tsvetkov +17 more
semanticscholar +1 more source
Programmed Cell Death in Cystinosis
Cells, 2022 Cystinosis is a lethal autosomal recessive disease that has been known clinically for over 100 years. There are now specific treatments including dialysis, renal transplantation and the orphan drug, cysteamine, which greatly improve the duration and ...
Elizabeth G. Ames, Jess G. Thoene
doaj +1 more source
Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Experimental and Molecular Medicine, 2023 Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate.
Thanh T Nguyen +15 more
semanticscholar +1 more source
Apoptosis, 2022 Research on cell death mechanisms gets a lot of attention. This is understandable as it underlies biology in general, as well as the insight in pathological conditions and the development of opportunities for therapeutic intervention. Over the last years a steady rise in the number of scientific reports and in the impact of this literature on the ...
Griffioen, Arjan W. +1 more
openaire +3 more sources
Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Cell Death and Disease, 2023 Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular proteins.
Zhen Xie +10 more
semanticscholar +1 more source
Programmed cell death in cerebellar Purkinje neurons [PDF]
Journal of Integrative Neuroscience, 2022 Apoptosis, autophagy and necrosis are the three main types of programmed cell death. One or more of these types of programmed cell death may take place in neurons leading to their death in various neurodegenerative disorders in humans.
Nour S. Erekat
doaj +1 more source
Programmed cell death detection methods: a systematic review and a categorical comparison
Apoptosis, 2022 Programmed cell death is considered a key player in a variety of cellular processes that helps to regulate tissue growth, embryogenesis, cell turnover, immune response, and other biological processes.
Sana Kari +5 more
semanticscholar +1 more source
Apoptosis: Programmed Cell Death [PDF]
Archives of Surgery, 1998 Currently there is much interest and excitement in the understanding of how cells undergo the process of apoptosis or programmed cell death. Understanding how, why, and when cells are instructed to die may provide insight into the aging process, autoimmune syndromes, degenerative diseases, and malignant transformation.
N K, Kuan, E, Passaro
openaire +2 more sources
Programmed cell death and liver diseases
Вестник трансплантологии и искусственных органов, 2022 Cell death represents the most critical pathologic entity in liver disease, which dictates pathologic consequences such as inflammation, fibrosis, and cell transformation.
N. A. Onishchenko +4 more
doaj +1 more source
Theranostics, 2021 In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated remarkable achievements. However, emerging evidence has shown that chemoresistance is mediated by impairing or bypassing apoptotic cell death.
Sheng-Kai Hsu +9 more
semanticscholar +1 more source