Results 51 to 60 of about 572,695 (365)

Effective description of bistability and irreversibility in apoptosis [PDF]

arXiv, 2021
Apoptosis is a mechanism of programmed cell death in which cells engage in a controlled demolition and prepare to be digested without damaging their environment. In normal conditions apoptosis is repressed, until it is irreversibly induced by an appropriate signal.
arxiv  

Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death [PDF]

Apoptosis (2010), 2010
BH3 mimetics have been proposed as new anticancer therapeutics. They target anti-apoptotic Bcl-2 proteins, up-regulation of which has been implicated in the resistance of many cancer cells, particularly leukemia and lymphoma cells, to apoptosis. Using probabilistic computational modeling of the mitochondrial pathway of apoptosis, verified by single ...
arxiv   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Calcium Signaling in Plant Programmed Cell Death

Cells, 2021
Programmed cell death (PCD) is a process intended for the maintenance of cellular homeostasis by eliminating old, damaged, or unwanted cells. In plants, PCD takes place during developmental processes and in response to biotic and abiotic stresses.
Huimin Ren, Xiaohong Zhao, Wenjie Li, Jamshaid Hussain, Guoning Qi, Shenkui Liu   +5 more
doaj   +1 more source

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans [PDF]

, 2012
Caspases are cysteine proteases that can drive apoptosis in metazoans and have critical functions in the elimination of cells during development, the maintenance of tissue homeostasis, and responses to cellular damage. Although a growing body of research
A Cauwels, A Degterev, A Gartner, A Raj, AH Wyllie, AM Chinnaiyan, B Conradt, B Pinan-Lucarre, B Schumacher, BT Hyman, D Xue, D Xue, Daniel P. Denning, DJ Dwyer, DJ Hoeppner, DP Denning, DT Harris, E Arama, E Pourkarimi, EC Andersen, EH Cheng, EM Hedgecock, ES Blum, F Chen, F Madeo, F Simmer, H. Robert Horvitz, HC Chang, Hermann Steller, HM Ellis, HT Schwartz, J Yuan, J Yuan, JE Sulston, JE Sulston, JF Kerr, JM Kinchen, JY Yuan, K Xu, M Darland-Ransom, MC Abraham, MC Abraham, MO Hengartner, MO Hengartner, NA Thornberry, PW Reddien, RA Lockshin, RE Ellis, S Brenner, S Harbinder, S Qi, S Seshagiri, S Shaham, S Shaham, S Shaham, SA Susin, T Hirose, TL Gumienny, V Venegas, VA Fadok, Victoria Hatch, X Geng, X Geng, X Wang, X Yang, Z Zhou   +65 more
core   +4 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis

Chinese Medical Journal, 2017
Objective: Sepsis remains a leading cause of death in many Intensive Care Units worldwide. Immunosuppression has been a primary focus of sepsis research as a key pathophysiological mechanism.
Qiang Liu, Chun-Sheng Li
doaj   +1 more source

Emergence of multicellularity in a model of cell growth, death and aggregation under size-dependent selection [PDF]

, 2014
How multicellular life forms evolved out from unicellular ones constitutes a major problem in our understanding of the evolution of our biosphere. A recent set of experiments involving yeast cell populations has shown that selection for faster sedimenting cells leads to the appearance of stable aggregates of cells that are able to split into smaller ...
arxiv   +1 more source

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source