Results 241 to 250 of about 287,893 (307)

Apoptosis in Temporomandibular Joint Disc with Internal Derangement Involves Mitochondrial-dependent Pathways. An \u3cem\u3ein vivo\u3c/em\u3e Study [PDF]

, 2013
Almeida, Luis Eduardo, Bartoloni, Giovani, Caltabiano, Rosario, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Rusu, Mugurel Constantin   +6 more
core   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms. [PDF]

World J Gastroenterol
Smirnova A, Eygel D, Kondrasheva I, Baranovskii DS, Klabukov ID.   +4 more
europepmc   +1 more source

Programmed Cell Death Receptor Ligand 1 Modulates the Regulatory T Cells’ Capacity to Repress Shock/Sepsis–Induced Indirect Acute Lung Injury by Recruiting Phosphatase Src Homology Region 2 Domain-Containing Phosphatase 1

, 2014
Lunxian Tang, Jianwen Bai, Chun‐Shiang Chung, Joanne Lomas‐Neira, Yaping Chen, Xin Huang, Alfred Ayala   +6 more
openalex   +2 more sources

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

Concordance of programmed death-ligand 1 expression assessments determined <i>via</i> two immunohistochemical tests and the polymerase chain reaction method. [PDF]

World J Exp Med
Senchukova MA, Saidler NV, Zubareva EY, Prokofiev AB, Tagabilev DG.   +4 more
europepmc   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

LEAP-006: limits and potential of integrating anti-angiogenic agents into first-line multimodal therapy for non-squamous non-small cell lung cancer. [PDF]

J Thorac Dis
Santo V, Garbo E, Pecci F, Aldea M, Ricciuti B, Gariazzo E.   +5 more
europepmc   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

shRNA-based PD-1 suppression preserves memory phenotype and function of CD19-targeted CAR-T cell. [PDF]

Transl Cancer Res
Zhao J, Wu H, Sun Z, Cui Y, Liu N, Wang Y, Wang Y, Shi J, Zhang T.   +8 more
europepmc   +1 more source