Results 251 to 260 of about 290,432 (308)
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Alcohol, 2020
Engagement of programmed death-1 (PD-1) receptor by its ligands (PD-L1/PD-L2) in activated immune cells is known to be involved in inflammatory neurological disease via a co-inhibitory signal pathway. Interaction of PD-1/PD-L1 is believed to occur only in activated neuroimmune cells because there are undetectable levels of PD-1/PD-L1 in normal ...
Vikas Mishra +4 more
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Engagement of programmed death-1 (PD-1) receptor by its ligands (PD-L1/PD-L2) in activated immune cells is known to be involved in inflammatory neurological disease via a co-inhibitory signal pathway. Interaction of PD-1/PD-L1 is believed to occur only in activated neuroimmune cells because there are undetectable levels of PD-1/PD-L1 in normal ...
Vikas Mishra +4 more
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Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2020
Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the oral and maxillofacial region. At present, the treatment of OSCC is mainly based on surgical oriented comprehensive sequence therapy, especially the triple therapy of surgery, radiotherapy, and chemotherapy. However, the overall five-year survival rate is relatively low.
Zhi-Hong, Chen, Ya-Dong, Wu
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Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the oral and maxillofacial region. At present, the treatment of OSCC is mainly based on surgical oriented comprehensive sequence therapy, especially the triple therapy of surgery, radiotherapy, and chemotherapy. However, the overall five-year survival rate is relatively low.
Zhi-Hong, Chen, Ya-Dong, Wu
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The p53/IGF-1 receptor axis in the regulation of programmed cell death
Endocrine, 1997The loss or functional inactivation of tumor suppressor genes appears to be one of the most fundamental genetic mechanisms of tumorigenesis, and rational insights into the signaling pathways of tumor suppressor genes have emerged as a successful strategy of identifying novel drug discovery targets downstream of the tumor suppressor protein itself ...
M, Neuberg +3 more
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Breast Cancer Research and Treatment, 2021
The interaction of the programmed cell death 1 (PD-1) receptor on tumor-infiltrating lymphocytes with programmed death ligand 1 (PD-L1) on tumor cells downregulates anti-tumor immunity. This study evaluated associations between PD-1 and PD-L1 expression in primary breast cancer, clinical characteristics, and patient outcomes.Microarray data from the ...
Neelima Vidula +2 more
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The interaction of the programmed cell death 1 (PD-1) receptor on tumor-infiltrating lymphocytes with programmed death ligand 1 (PD-L1) on tumor cells downregulates anti-tumor immunity. This study evaluated associations between PD-1 and PD-L1 expression in primary breast cancer, clinical characteristics, and patient outcomes.Microarray data from the ...
Neelima Vidula +2 more
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Animal Reproduction Science
Programmed cell death (PD) ligand 1 (PDL1) and PDL2 and their receptor PD1 play critical roles in immunity, and an involvement of the PDL1/PDL2-PD1 signaling system in the immune tolerance during pregnancy has been suggested in humans. However, the role of the PDL1/PDL2-PD1 signaling system at the maternal-conceptus interface has not been studied in ...
Inkyu Yoo +5 more
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Programmed cell death (PD) ligand 1 (PDL1) and PDL2 and their receptor PD1 play critical roles in immunity, and an involvement of the PDL1/PDL2-PD1 signaling system in the immune tolerance during pregnancy has been suggested in humans. However, the role of the PDL1/PDL2-PD1 signaling system at the maternal-conceptus interface has not been studied in ...
Inkyu Yoo +5 more
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Pathobiology
Introduction: This study aimed to evaluate the prognostic significance of programmed cell death (PD)-1/PD-ligand 1 (PD-L1), PD-ligand 2 (PD-L2), and fibroblast growth factor receptor 3 (FGFR3) expression in bladder cancer (BC). Methods: A retrospective study was conducted on BC patients who underwent transurethral resection between 2005 and 2014.
Ana Blanca +6 more
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Introduction: This study aimed to evaluate the prognostic significance of programmed cell death (PD)-1/PD-ligand 1 (PD-L1), PD-ligand 2 (PD-L2), and fibroblast growth factor receptor 3 (FGFR3) expression in bladder cancer (BC). Methods: A retrospective study was conducted on BC patients who underwent transurethral resection between 2005 and 2014.
Ana Blanca +6 more
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Anti‐program cell death receptor‐1 induced erythema nodosum
Dermatologic Therapy, 2022Caroline Gerhardt +5 more
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Veterinary Immunology and Immunopathology
Immunomodulatory antibody drugs that modulate the function of immune checkpoint molecules, such as programmed death receptor-1 (PD-1) and programmed cell death ligand 1 (PD-L1), have been established as new cancer treatments in human medicine. In recent years, there have also been reports on antibodies that inhibit immune checkpoint molecules in dogs ...
Takuya, Mizuno +3 more
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Immunomodulatory antibody drugs that modulate the function of immune checkpoint molecules, such as programmed death receptor-1 (PD-1) and programmed cell death ligand 1 (PD-L1), have been established as new cancer treatments in human medicine. In recent years, there have also been reports on antibodies that inhibit immune checkpoint molecules in dogs ...
Takuya, Mizuno +3 more
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Magyar onkologia, 2019
In the past years, immunotherapy emerged as a novel modality of clinical oncology. The development and introduction of immune checkpoint inhibitors required the development of companion diagnostics, the PD-L1 protein immunohistochemical tests. Unfortunately, almost all checkpoint inhibitors were exclusively validated by a specific PD-L1 in vitro ...
Gábor, Lotz +4 more
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In the past years, immunotherapy emerged as a novel modality of clinical oncology. The development and introduction of immune checkpoint inhibitors required the development of companion diagnostics, the PD-L1 protein immunohistochemical tests. Unfortunately, almost all checkpoint inhibitors were exclusively validated by a specific PD-L1 in vitro ...
Gábor, Lotz +4 more
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Ipilimumab/programmed-cell-death-1-receptor-antagonists
Reactions Weekly, 2020openaire +2 more sources