Results 131 to 140 of about 35,120,764 (296)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Programmed death-1 ligand 2-mediated regulation of the PD-L1 to PD-1 axis is essential for establishing CD4⁺ T cell immunity

, 2016
Many pathogens, including Plasmodium spp., exploit the interaction of programmed death-1 (PD-1) with PD-1-ligand-1 (PD-L1) to "deactivate" T cell functions, but the role of PD-L2 remains unclear.
Lee, Jason S., Sharpe, Arlene H., Yarski, Michael, Stacey, Katryn, Dwyer, Patrick, Horne-Debets, Joshua M., Cooper, Matthew, Miles, John J., Horne-Debets, Joshua, Karunarathne, Deshapriya, Faleiro, Rebecca, Watkins, Thomas, Huang, Johnny X., Sharpe, Arlene, Leow, Chiuan Yee, Karunarathne, Deshapriya S., Rénia, Laurent, Wykes, Michelle, Wykes, Michelle N., Lee, Jason, Watkins, Thomas S., Richard, Derek, Huang, Johnny, McCarthy, James, Amante, Fiona, Dwyer, Patrick J., Chiuan Yee, Leow, Poh, Chek Meng, Miles, John, Cooper, Matthew A., Stacey, Katryn J., McCarthy, James S.   +31 more
core   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

Identification of PD-1–PD-L1 blockade epitopes in vitro utilizing porcine immunoglobulin and heterologous Fc-fused protein

Veterinary Research
Programmed death 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1), function as pivotal immune checkpoints. Numerous studies have demonstrated the association between the malignant progression of various swine diseases and aberrant expression of
Yuwen Dong, Xin Li, Zuxin Gong, Chenchen Liu, Jiaqi Dai, Shuhuai Shen, Zhen Yang, Gongguan Liu   +7 more
doaj   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Microbiome Modulation in Lung Cancer Immunotherapy: Unveiling the Role of Respiratory and Gut Microbiota in the PD-1/PD-L1 Response

Frontiers in Bioscience-Landmark
Lung cancer, the leading cause of cancer-related mortality worldwide, poses considerable therapeutic challenges due to the varied responses to programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors.
Yuanyuan Xu, Yixing Tao, Hanbo Pan, Zhongjie Wang, Hui Wang, Qingquan Luo   +5 more
doaj   +1 more source

Programmed Cell Death 1 Ligand 1 [PDF]

, 2020
openaire   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Clinical impact of programmed cell death ligand 1 expression in colorectal cancer

, 2013
BACKGROUND Programmed cell death 1 (PD-1) receptor triggering by PD ligand 1 (PD-L1) inhibits T cell activation. PD-L1 expression was detected in different malignancies and associated with poor prognosis.
Nebiker, Christian, Spagnoli, G. C., Tornillo, Luigi, Zuber, M., Terracciano, L., Amicarella, Francesca, Droeser, Raoul A., Tzankov, A., Spagnoli, Giulio C., Luigi Terracciano, Oertli, Daniel, Huber, Xaver, Viehl, C. T., Muraro, Manuele Giuseppe, Carsten T. Viehl, Hirt, C., Viehl, Carsten T., Alessandro Lugli, Cremonesi, Eleonora, Zlobec, I., Eleonora Cremonesi, Daniel M. Frey, Frey, Daniel M., Eppenberger-Castori, Serenella, Iezzi, G., Terracciano, Luigi, Sconocchia, G., Xaver Huber, Muraro, M. G., Markus Zuber, Zuber, Markus, Hirt, Christian, Serenella Eppenberger-Castori, Heberer, Michael, Michael Heberer, Giandomenica Iezzi, Rosso, R., Droeser, R. A., Inti Zlobec, Frey, D. M., Raffaele Rosso, Lugli, Alessandro, Tzankov, Alexander, Rosso, Raffaele, Tornillo, L., Nebiker, C., Luigi Tornillo, Lugli, A., Cremonesi, E., Giulio C. Spagnoli, Zlobec, Inti, Alexander Tzankov, Sconocchia, Giuseppe, Francesca Amicarella, Eppenberger-Castori, S., Christian Hirt, Amicarella, F., Daniel Oertli, Christian Nebiker, Huber, X., Manuele Giuseppe Muraro, Raoul A. Droeser, Oertli, D., Giuseppe Sconocchia, Heberer, M., Iezzi, Giandomenica   +65 more
core   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source