Results 31 to 40 of about 35,120,764 (296)

Prevalence of programmed death ligand-1 in patients diagnosed with non-small cell lung cancer in Lebanon

SAGE Open Medicine, 2021
Introduction: Programmed death ligand-1 expression has been shown to be a good predictor of response to cancer therapy with checkpoint inhibitors. Its expression varies among different tumor types and among non-small cell lung cancer patients with ...
Ghina Fakhri, Reem Akel, Ibrahim Khalifeh, Hassan Chami, Adel Hajj Ali, Majd Al Assaad, Haneen Atwi, Humam Kadara, Arafat Tfayli   +8 more
doaj   +1 more source

Programmed cell death in type II neuroblast lineages is required for central complex development in the Drosophila brain [PDF]

, 2012
Background: The number of neurons generated by neural stem cells is dependent upon the regulation of cell proliferation and by programmed cell death.
Heinrich Reichert, Reichert, Heinrich, Yanrui Jiang, Reichert Heinrich, Jiang Yanrui, Jiang, Yanrui   +5 more
core   +1 more source

Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites [PDF]

, 2011
Apoptosis-like programmed cell death (PCD) has recently been described in multiple taxa of unicellular protists, including the protozoan parasites Plasmodium, Trypanosoma and Leishmania.
Sarah E Reece, Szymon Kaczanowski, Reece, Sarah E., Kaczanowski Szymon, Kaczanowski, S., Reece, S.E., Reece Sarah E, Mohammed Sajid, Sajid Mohammed, Sajid, M., Reece, Sarah, Sajid, Mohammed, Kaczanowski, Szymon   +12 more
core   +1 more source

Programmed Cell Death-1/Programmed Cell Death Ligand-1 Checkpoint Inhibitors: Differences in Mechanism of Action [PDF]

Immunotherapy, 2019
Programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) checkpoint inhibitors are widely used in many types of solid tumors, and are often considered to be in the same immunotherapy subclass. This review explores whether specific agents in these two categories exhibit differences in their mechanism of action, pharmacokinetics and ...
Ni, Zhang, Jingyao, Tu, Xue, Wang, Qian, Chu   +3 more
openaire   +2 more sources

Programmed cell death protein 1 and programmed death ligand 1 expression in neuroendocrine carcinomas of the urinary bladder

Polish Journal of Pathology, 2021
Neuroendocrine carcinomas (NECs) of the urinary bladder are rare and aggressive, without an effective treatment approach. Immune checkpoint inhibitor agents targeting the interaction of programmed cell death protein 1 (PD-1) and programmed death ligand 1
Arbil Acikalin, Emine Bagir, Merve Inceman, Mutlu Deger, Seyda Erdogan   +4 more
doaj   +1 more source

PD‐1/L1 inhibitors can improve but not replace chemotherapy for advanced urothelial carcinoma: A systematic review and network meta‐analysis

Cancer Innovation, 2023
Background Programmed cell death‐1/ligand 1 inhibitors are a new treatment strategy for advanced urothelial carcinoma. Therefore, a comparative evaluation of their efficacy and toxicity compared with chemotherapy is necessary.
Longkun Mao, Meihua Yang, Xinxiang Fan, Wenjie Li, Xiaodong Huang, Wang He, Tianxin Lin, Jian Huang   +7 more
doaj   +1 more source

Regulation of cell death in cancer - possible implications for immunotherapy [PDF]

, 2013
Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape.
Simone Fulda, Simone eFulda, Fulda, Simone   +2 more
core   +1 more source

Programmed Death Ligand 1; An Immunotarget for Renal Cell Carcinoma [PDF]

Asian Pacific Journal of Cancer Prevention, 2019
In this era of developing targeted therapies and immunotherapies as a treatment for renal cell carcinoma (RCC), Programmed death ligand 1 (PDL1) as a novel biomarker for RCC is analysed in our study. About 90% of all renal cancers are Renal Cell Carcinoma. Most cases are diagnosed incidentally. 17% of cases are advanced at the time of diagnosis.
Chandrasekaran, Deepika, Sundaram, Sandhya, N, Kadhiresan, R, Padmavathi   +3 more
openaire   +2 more sources

Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]

, 2012
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Gabor Barna (146087), Pal I Bauer, Istvan Petak, Mihalik, Rudolf, Zsuzsanna A Dunai, Gergely Imre, Istvan Petak (5648680), Pal I. Bauer (144904), Gergely Imre (146083), Imre, Gergely, Tamas Korcsmaros, Dunai, Zsuzsanna A., Barna, Gabor, Rudolf Mihalik, Bauer, Pal I., Gabor Barna, Rudolf Mihalik (146097), Petak, Istvan, Zsuzsanna A. Dunai (144901), Korcsmaros, Tamas, Tamas Korcsmaros (146091)   +20 more
core   +2 more sources

The incidence of pseudoprogressive disease associated with programmed cell death 1/programmed cell death ligand 1 inhibitors

Medicine, 2021
Abstract Background: The method to evaluate the efficacy of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors has become a big concern for researchers with its widely application. Pseudoprogressive disease (PPD) makes this process more difficult, which means that the tumor progressed at ...
Jingyi Zhang, Kexin Tan, Xuejiao Jiang, Shuyue Zheng, Jia Li, Chongxiang Xue, Xu Zhang, Huijuan Cui   +7 more
openaire   +2 more sources