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Expression of programmed cell death protein 1 and programmed cell death ligand 1 in feline injection site fibrosarcomas

Research in Veterinary Science
Feline injection site fibrosarcomas represent a unique challenge in veterinary oncology due to their association with injection sites and aggressive behaviour. The study explores the expression of immune checkpoints programmed cell death protein 1 and programmed cell death ligand 1 in the malignancy, aiming to unravel their potential significance in ...
Mateusz, Mikiewicz   +3 more
openaire   +2 more sources

Risk monitoring and pharmacovigilance of programmed cell death protein 1 / programmed cell death 1 ligand 1 in cancer patients after solid organ transplantation

Therapies, 2023
Several medications are available for the treatment of cancer, and monoclonal antibodies that target PD-1 and PD-L1 represent first-line options for cancer. PD-1 promotes the ability of the immune system to recognize and attack cancer cells by activating T cells. PD-1 also activates the autoimmune system.
Long, Mei   +6 more
openaire   +2 more sources

Intratumoral CD39+CD8+ T Cells Predict Response to Programmed Cell Death Protein-1 or Programmed Death Ligand-1 Blockade in Patients With NSCLC

Journal of Thoracic Oncology, 2021
Programmed cell death protein-1 (PD-1) and programmed death-ligand 1 (PD-L1) blockade is currently widely used in the treatment of metastatic NSCLC. Despite available biomarker stratification, clinical responses vary. Thus, the search for novel biomarkers with improved response prediction is ongoing.
Joe, Yeong   +14 more
openaire   +2 more sources

Programmed cell death protein 1/programmed death ligand 1 but not HER2 is a potential therapeutic target in gastric neuroendocrine carcinoma

Histopathology, 2020
AimsGastric neuroendocrine carcinoma (NEC) is a rare and aggressive subtype with a poor prognosis. We aim to investigate expression profiles of HER2 and programmed death ligand 1 (PD‐L1) in gastric NEC to test the potential applicability of drugs targeting these molecules.Methods and resultsExpression levels of HER2 and PD‐L1 were evaluated in 25 ...
Satoshi Yamashita   +5 more
openaire   +2 more sources

The programmed cell death protein 1 (PD1) and the programmed cell death ligand 1 (PD-L1) are significantly downregulated on macrophages and Hofbauer cells in the placenta of preeclampsia patients

Journal of Reproductive Immunology, 2023
Preeclampsia is a pregnancy-specific disease which is characterized by abnormal placentation, endothelial dysfunction, systemic inflammation and disruption of the immune system. The goal of this study was to characterize the PD-1/PD-L1 system, an important immune checkpoint system, on macrophages and Hofbauer cells (HBC) in the placenta of preeclamptic
Johanna Mittelberger   +9 more
openaire   +3 more sources

Programmed cell death protein 1 and vitiligo

International Journal of Dermatology, 2019
Xiran, Lin, Xianmin, Meng, Zhiqi, Song
openaire   +2 more sources

Programmed Cell Death Protein 1 (PD-1) in Relation to PANoptosis: Immune Pharmacological Targets for Management of Breast Adenocarcinoma

Endocrine, Metabolic and Immune Disorders - Drug Targets, 2023
, Souvik Paul, Pallab Kanti Haldar
exaly  

Prognostic implication of programmed cell death 1 protein and programmed cell death 1 ligand 1 expression in endometrial cancer

Gynecologic Oncology, 2018
J. Kim   +6 more
openaire   +1 more source

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