Results 41 to 50 of about 380,241 (288)

Impact of endogenous glucocorticoid on response to immune checkpoint blockade in patients with advanced cancer

Frontiers in Immunology, 2023
BackgroundPrevious studies indicate that exogenous use of glucocorticoid (GC) affects immune checkpoint inhibitor (ICI) efficacy. However, there is a paucity of clinical data evaluating the direct impact of endogenous GC on the efficacy for cancer ...
Yu Cui, Yu Cui, Yu Cui, Xinyue Han, Xinyue Han, Xinyue Han, Hongtao Liu, Qi Xie, Qi Xie, Qi Xie, Yaping Guan, Yaping Guan, Yaping Guan, Beibei Yin, Beibei Yin, Beibei Yin, Junjuan Xiao, Junjuan Xiao, Junjuan Xiao, Dongfeng Feng, Dongfeng Feng, Dongfeng Feng, Xuan Wang, Xuan Wang, Xuan Wang, Junwei Li, Junwei Li, Junwei Li, Jinghua Chen, Jinghua Chen, Jinghua Chen, Xiaolin Liu, Xiaolin Liu, Xiaolin Liu, Xingyu Li, Xingyu Li, Xingyu Li, Weiwei Nie, Weiwei Nie, Weiwei Nie, Lin Ma, Lin Ma, Lin Ma, Hairong Liu, Hairong Liu, Hairong Liu, Jing Liang, Jing Liang, Jing Liang, Yan Li, Yan Li, Yan Li, Baocheng Wang, Jun Wang, Jun Wang, Jun Wang   +55 more
doaj   +1 more source

Identification of an expanded binding surface on the FADD death domain responsible for interaction with CD95/Fas [PDF]

, 2004
The initiation of programmed cell death at CD95 (Fas, Apo-1) is achieved by forming a death-inducing signaling complex (DISC) at the cytoplasmic membrane surface.
Hill, J. M., Huang, T., Kim, T., Morisawa, G., Wei, Y., Wei, Y. F., Werner, M. H.   +6 more
core   +1 more source

Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death [PDF]

, 2006
Histolysis refers to a widespread disintegration of tissues that is morphologically distinct from apoptosis and often associated with the stimulation of autophagy. Here, we establish that a component of the apoptosome, and pivotal regulator of apoptosis,
Abrams, John M., Akdemir, Fatih, Chen, Po, Chittaranjan, Suganthi, Farkas, Robert, Gorski, Sharon M., Juhász, Gábor, Medved'ová, Lucia, Rodriguez, Antony, Sass, Miklós, Wang, Lai, Wang, Xiaodong   +11 more
core   +1 more source

Chinese Experts Consensus on Immune Checkpoint Inhibitors 
for Non-small Cell Lung Cancer (2020 Version)

Chinese Journal of Lung Cancer, 2021
Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. The systemic antitumor therapy of advanced NSCLC has undergone renovations of chemotherapy, targeted therapy and immunotherapy, which results in greatly improved ...
Caicun ZHOU, Jie WANG, Baocheng WANG, Ying CHENG, Zhehai WANG, Baohui HAN, You LU, Gang WU, Li ZHANG, Yong SONG, Bo ZHU, Yi HU, Ziping WANG, Qibin SONG, Shengxiang REN, Yayi HE, Xiaohua HU, Jian ZHANG, Yu YAO, Hongyun ZHAO, Zhijie WANG, Qian CHU, Jianchun DUAN, Jingjing LIU, Shukui QIN   +24 more
doaj   +1 more source

External and internal triggers of cell death in yeast [PDF]

, 2016
In recent years, yeast was confirmed as a useful eukaryotic model system to decipher the complex mechanisms and networks occurring in higher eukaryotes, particularly in mammalian cells, in physiological as well in pathological conditions.
FALCONE, Claudio, MAZZONI, Cristina
core   +2 more sources

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis [PDF]

, 2016
Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined.
Andreas E. Kremer, Andreas Linkermann, Babon, Cai, Christin Dewitz, Christoph Becker, Christopher Poremba, Claudia Günther, Deutsch, Dusheiko, Emma J. Petrie, Gui-Wei He, James M. Murphy, Kang, Kerstin Amann, Ma, Manns, Marinescu, Markus F. Neurath, Peter Vandenabeele, Pine, Siebler, Stefan Krautwald, Stefan Wirtz, Ulrike Schleicher   +24 more
core   +1 more source

The correlation between the costs and clinical benefits of PD-1/PD-L1 inhibitors in malignant tumors: An evaluation based on ASCO and ESMO frameworks

Frontiers in Pharmacology, 2023
Background: Life expectancy for patients with malignant tumors has been significantly improved since the presence of the programmed cell death protein-1/programmed cell death protein ligand-1 (PD-1/PD-L1) inhibitors in 2014, but they impose heavy ...
Shen Lin, Shen Lin, Yaping Huang, Yaping Huang, Liangliang Dong, Meiyue Li, Yahong Wang, Dian Gu, Wei Wu, Wei Wu, Dongni Nian, Dongni Nian, Shaohong Luo, Shaohong Luo, Xiaoting Huang, Xiaoting Huang, Xiongwei Xu, Xiongwei Xu, Xiuhua Weng, Xiuhua Weng   +19 more
doaj   +1 more source

Progress of research on PD-1/PD-L1 in leukemia

Frontiers in Immunology, 2023
Leukemia cells prevent immune system from clearing tumor cells by inducing the immunosuppression of the bone marrow (BM) microenvironment. In recent years, further understanding of the BM microenvironment and immune landscape of leukemia has resulted in ...
Huizhen Cao, Tianyu Wu, Xue Zhou, Shuyang Xie, Hongfang Sun, Yunxiao Sun, Youjie Li   +6 more
doaj   +1 more source

echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases [PDF]

, 2007
Background: Programmed cell death is used to remove excess cells between ommatidia in the Drosophila pupal retina. This death is required to establish the crystalline, hexagonal packing of ommatidia that characterizes the adult fly eye.
Bosdet, Ian, Copeland, Jeffrey M., Freeman, J. Douglas, Gorski, Sharon M., Guo, Ming, Hay, Bruce A.   +5 more
core   +4 more sources

Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy

Frontiers in Immunology, 2021
The tumor microenvironment (TME) is a complex ecosystem, which includes many different types of cells, abnormal vascular systems, and immunosuppressive cytokines.
Qin Qiu, Yuqi Lin, Yucui Ma, Xiaoling Li, Juan Liang, Zhiyan Chen, Kaifeng Liu, Yuge Huang, Hui Luo, Riming Huang, Lianxiang Luo, Lianxiang Luo, Lianxiang Luo   +12 more
doaj   +1 more source