Results 71 to 80 of about 380,241 (288)

PD-1 and PD-L1 are more highly expressed in high-grade bladder cancer than in low-grade cases: PD-L1 might function as a mediator of stage progression in bladder cancer

BMC Urology, 2018
Background Bladder cancers have been characterized as a tumor group in which the immunological response is relatively well preserved. Programmed death ligand 1 (PD-L1, B7-H1, CD274) has been shown to be expressed in several malignancies, including ...
Takashi Kawahara, Yukari Ishiguro, Shinji Ohtake, Ikuma Kato, Yusuke Ito, Hiroki Ito, Kazuhide Makiyama, Keiichi Kondo, Yasuhide Miyoshi, Yasushi Yumura, Narihiko Hayashi, Hisashi Hasumi, Kimito Osaka, Kentaro Muraoka, Koji Izumi, Jun-ichi Teranishi, Hiroji Uemura, Masahiro Yao, Noboru Nakaigawa   +18 more
doaj   +1 more source

Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes

Cancer Cell International, 2021
Background Immunotherapy has shown promising efficacy in patients with nasopharyngeal carcinoma (NPC). Lymphocyte activating 3 gene (LAG-3) represents a significant immune target, however, its relationship with NPC remains unclear.
Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang, Hongyun Zhao   +7 more
doaj   +1 more source

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. [PDF]

, 2019
Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a randomized, multi-institution clinical trial to evaluate immune responses ...
Arrillaga-Romany, Isabel C, Butowski, Nicholas A, Clarke, Jennifer L, Cloughesy, Timothy F, Cohen, Adam L, Colman, Howard, Davidson, Tom B, de Groot, John F, Du, Lin, Ellingson, Benjamin M, Gaffey, Sarah C, Hugo, Willy, Kaley, Thomas J, Kawaguchi, Eric S, Lee, Alexander H, Lee, Eudocia Q, Li, Gang, Liau, Linda M, Mellinghoff, Ingo K, Mochizuki, Aaron Y, Nghiemphu, Phioanh L, O'Brien, Barbara J, Orpilla, Joey R, Prins, Robert M, Reardon, David A, Rytlewski, Julie A, Sanders, Catherine M, Wang, Anthony C, Wen, Patrick Y, Yong, William H   +29 more
core  

Management of Adverse Events in Cancer Patients Treated With PD-1/PD-L1 Blockade: Focus on Asian Populations

Frontiers in Pharmacology, 2019
The interaction between programmed cell death protein 1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) induces exhaustions of cytotoxic lymphocytes in the tumor microenvironment, which facilitates tumor immune evasion.
Jiqiao Yang, Jiqiao Yang, Jiqiao Yang, Xiujing He, Xiujing He, Qing Lv, Qing Lv, Jing Jing, Hubing Shi, Hubing Shi   +9 more
doaj   +1 more source

Effect of Insulin-Like Growth Factor-1 (IGF-1) on the expression of NFκB and cFLIP in Bovine Granulosa Cells [PDF]

, 2014
Infertility, often attributed to follicular atresia, is a growing problem in the agricultural industry. Programmed cell death, also known as apoptosis, is a contributing factor of follicular atresia.
Docos, Samantha Kathleen
core   +1 more source

Alternative cell death pathways and cell metabolism [PDF]

, 2013
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells.
Fulda, Simone
core   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Striking enhancement at the site of radiation for nivolumab-induced Stevens-Johnson syndrome [PDF]

, 2018
Stevens-Johnson syndrome is a rare adverse cutaneous drug reaction characterized by epidermal detachment of
Al-Omari, Ahmed, Rancour, Elizabeth A., Shah, Kishan M.   +2 more
core  

Escherichia coli induces apoptosis and proliferation of mammary cells [PDF]

, 2001
Mammary cell apoptosis and proliferation were assessed after injection of Escherichia coli into the left mammary quarters of six cows. Bacteriological analysis of foremilk samples revealed coliform infection in the injected quarters of four cows.
AD Metcalfe, AJ Bramley, AV Capuco, AV Capuco, AW Hill, AW Hill, B Zavizion, BR Rueda, C Kampf, C Legrand, CA Wesson, CB Thompson, CM Alexander, CR Roh, DA Siwik, DE Shuster, DE Shuster, GM Swank, GR Merlo, H Heermeier, JM Adams, JS Hogan, K Schorr, K Schorr, KB Reddy, KR Matthews, KW Bayles, LA Rudolph-Owen, LG Sheffield, LR Lund, M Colitti, M Li, M Li, ME Burow, MM Keane, N Boudjellab, N Boudreau, NA Thornberry, NR Keller, P Maloof, PA Furth, R Blowey, R Strange, RB Hazan, RJ Eberhart, RJ Eberhart, S Ohta, S Pullan, T Tanaka, UK Mebmer, VC Farr, X Li, YJ Tzeng   +52 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source