Results 1 to 10 of about 542,975 (311)

Emerging role of the immunotherapy in treatment of breast cancer

SVU - International Journal of Medical Sciences, 2021
Background: Breast cancer is a life-threatening malignant tumor that ranks the most frequent cancerin females worldwide. Emerging studies suggest the important role of the immunotherapy in breast cancer.Triple negative breast cancer (TNBC) is associated ...
Nagwa Abd El-Sadek Ahmed*, Maisa Hashem Mohammed   +1 more
doaj   +1 more source

PD-L1 Expression and Combined Status of PD-L1/PD-1–Positive Tumor Infiltrating Mononuclear Cell Density Predict Prognosis in Glioblastoma Patients [PDF]

Journal of Pathology and Translational Medicine, 2017
Background Programmed death ligand 1 (PD-L1) in tumor cells is known to promote immune escape of cancer by interacting with programmed cell death 1 (PD-1) in tumor infiltrating immune cells.
Jiheun Han, Yongkil Hong, Youn Soo Lee
doaj   +1 more source

Expression and Significance of PD-1, PD-L1 and PD-L2 in T Cell Subsets and Myeloma Cells in Newly Diagnosed Multiple Myeloma Patients

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the expression of PD-1 and PD-L1/2 in T cell subsets and myeloma cells in the bone marrow from newly diagnosed multiple myeloma (NDMM) patients and their relation with clinical features.
MA Yinjuan, YANG Ke, YANG Xiaying, BAI Jiaofeng, BAI Hai, WU Tao, FU Lihua, JIANG Junfeng, PAN Yaozhu   +8 more
doaj   +1 more source

Inhibition of Programmed Death Receptor-1/Programmed Death Ligand-1 Interactions by Ginsenoside Metabolites

Molecules, 2020
Evidence suggests that programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) targeted inhibitors act as an immune checkpoint blockade, indicating that these compounds may be useful in cancer immunotherapy by inhibiting the immune response ...
Nam-Hui Yim, Young Soo Kim, Hwan-Suck Chung   +2 more
doaj   +1 more source

GLUT1 as a Prognostic Factor for Classical Hodgkin’s Lymphoma: Correlation with PD-L1 and PD-L2 Expression [PDF]

Journal of Pathology and Translational Medicine, 2017
Background Glucose transporter type 1 (GLUT1) expression is linked to glucose metabolism and tissue hypoxia. A recent study reported that GLUT1 was significantly associated with programmed death ligand 1 (PD-L1) as a therapeutic target in relapsed or ...
Young Wha Koh, Jae-Ho Han, Seong Yong Park, Dok Hyun Yoon, Cheolwon Suh, Jooryung Huh   +5 more
doaj   +1 more source

Programmed death‐ligand 1 expression in swine chronic infections and enhancement of interleukin‐2 production via programmed death‐1/programmed death‐ligand 1 blockade

Immunity, Inflammation and Disease, 2021
Introduction Chronic infections lead to the functional exhaustion of T cells. Exhausted T cells are phenotypically differentiated by the surface expression of the immunoinhibitory receptor, such as programmed death‐1 (PD‐1).
Otgontuya Ganbaatar, Satoru Konnai, Tomohiro Okagawa, Yutaro Nojima, Naoya Maekawa, Yoshiki Ichikawa, Atsushi Kobayashi, Tomoyuki Shibahara, Yojiro Yanagawa, Hidetoshi Higuchi, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi   +13 more
doaj   +1 more source

Assessment of PD-L1 expression in patients with neuroblastoma and renal tumors

The Turkish Journal of Pediatrics, 2021
Background. Programmed death 1 (PD-1) is a co-receptor which is located at the surface of cells like natural killer, monocytes, T and B cells. It has two ligands including programmed death ligand-1 (PD-L1) and ligand-2 (PD-L2).
Seher Şener, Aylar Poyraz, Arzu Okur, Faruk Güçlü Pınarlı, Ceyda Karadeniz   +4 more
doaj   +1 more source

Programmed death ligand-1/programmed death-1 inhibition therapy and programmed death ligand-1 expression in urothelial bladder carcinoma

Chronic Diseases and Translational Medicine, 2019
After two decades of unchanged paradigms, the treatment strategies for advanced urothelial bladder cancer have been revolutionized by emerging programmed death ligand-1 (PD-L1)/programmed death-1 (PD1) inhibition therapy.
Wei-Bo Yu, Jian-Yu Rao
doaj   +1 more source

Programmed death-1 (PD-1) ligand 1 and PD-1 ligand 2 expressions and their clinical relevance in colorectal cancer [PDF]

Korean Journal of Clinical Oncology, 2017
Purpose Programmed death-1 and its ligands (PD-L1 and PD-L2) can induce T-cell apoptosis in many solid tumors, although there is limited information regarding their roles in colorectal cancer.
Jee Hyun Ahn, Hyun Yong Lee, Dong Hyun Kang, Geum Jong Song, Tae Sung Ahn, Myoung Won Son, Moon Soo Lee, Moo-Jun Baek   +7 more
doaj   +1 more source

Expression of programmed death-ligand 1 and programmed death-1 in patients with extramammary paget's disease

Indian Journal of Dermatology, 2021
Background: Extramammary Paget's disease (EMPD) is a rare skin cancer and sometimes has fatal prognosis. For progressive cases, therapeutic options are limited.
Hiroyuki Goto, Kazunari Sugita, Osamu Yamamoto   +2 more
doaj   +1 more source