Results 81 to 90 of about 218,137 (295)

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma [PDF]

, 2017
Background Immune checkpoint inhibitors targeting programmed cell death 1 (PD1) or its ligand (PD-L1) showed activity in several cancer types. Methods We performed immunohistochemistry for CD3, CD8, CD20, HLA-DR, phosphatase and tensin homolog (PTEN), PD-
Berghoff, Anna Sophie, Brandstetter, Anita, Dieckmann, Karin, Filipits, Martin, Hainfellner, Johannes A., Hegi, Monika E., Kiesel, Barbara, Kurscheid, Sebastian, Marosi, Christine, Preusser, Matthias, Rajky, Orsolya, Ricken, Gerda, Weller, Michael, Wick, Wolfgang, Widhalm, Georg, Wöhrer, Adelheid, Zielinski, Christoph C.   +16 more
core  

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

Prognostic Value of Programmed Death Ligand 1 and Programmed Death 1 Expression in Thymic Carcinoma [PDF]

Clinical Cancer Research, 2016
Abstract Purpose: The immune checkpoint of the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is believed to play an important role in evasion of host antitumor immune surveillance in various malignancies; however, little is known about its role in thymic carcinoma.
Shintaro, Yokoyama, Hiroaki, Miyoshi, Kazutaka, Nakashima, Joji, Shimono, Toshihiro, Hashiguchi, Masahiro, Mitsuoka, Shinzo, Takamori, Yoshito, Akagi, Koichi, Ohshima   +8 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Assessment of programmed cell death 1 and its programmed cell death ligand 1 levels in vitiligo

Journal of the Egyptian Women’s Dermatologic Society
Background Programmed cell death 1 (PD-1) is a cell surface protein that serves as an immune checkpoint in conjunction with its two ligands, PD-L1 and PD-L2.
Hanan R. Nada, Ahmed Mourad, Laila A. Rashed, Ghada M. El-Hanafy, Nermeen M.A. Abdallah, Mohamed M. Abdelhady   +5 more
doaj   +1 more source

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications [PDF]

, 2020
Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from ...
Brém, Elizabeth, Koyfman, Alex, Long, Brit Jeffrey   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer

Therapeutic Advances in Gastroenterology, 2016
Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor ...
Xiaojun Liu, Zhongxia Yang, Olivier Latchoumanin, Liang Qiao   +3 more
doaj   +1 more source

Regulation of Neuroinflammation through Programmed Death-1/Programmed Death Ligand Signaling in Neurological Disorders

Frontiers in Cellular Neuroscience, 2014
Immune responses in the central nervous system (CNS), which involve both resident glial cells and infiltrating peripheral immune cells, play critical roles in the progress of brain injuries and neurodegeneration.
Shangfeng eZhao, Shangfeng eZhao, fengwu eli, Rehana K Leak, Jun eChen, Xiaoming eHu, Xiaoming eHu   +6 more
doaj   +1 more source

Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors. [PDF]

, 2019
The tremendous clinical success of immune checkpoint inhibition (ICI), particularly targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1/2 (PD-L1/2) pathway, has resulted in application to multiple cancers, as a monotherapy and ...
Le, Catherine T, Murphy, William J
core   +1 more source