Results 261 to 270 of about 218,137 (295)

Pescadillo ribosomal biogenesis factor 1 and programmed death-ligand 1 in gastric and head and neck squamous cell carcinoma. [PDF]

World J Gastroenterol
Hu XN, Li CF, Huang SM, Nie CL, Pang R.
europepmc   +1 more source

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Programmed death ligand 1 signals in cancer cells

Nature Reviews Cancer, 2022
The paradigm of surface-expressed programmed death ligand 1 (PDL1) signalling to immune cell programmed death 1 (PD1) to inhibit antitumour immunity has helped to develop effective and revolutionary immunotherapies using antibodies blocking these cell-extrinsic interactions.
Anand V. R. Kornepati, Ratna K. Vadlamudi, Tyler J. Curiel   +2 more
openaire   +2 more sources

Targeting the programmed death-1/programmed death-ligand 1 axis in lymphoma

Current Opinion in Oncology, 2015
The development of 'immune checkpoint inhibitors' or drugs targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis has been a stunning success of cancer immunotherapy. This review provides a timely overview of the biology and function of the PD-1 pathway and discusses the rationale for therapeutic inhibition of this pathway in ...
Chan Yoon, Cheah, Nathan H, Fowler, Sattva S, Neelapu   +2 more
openaire   +3 more sources

The role of programed death-ligand 1 in renal diseases

Journal of Receptors and Signal Transduction, 2020
Programed death-ligand 1 (PD-L1, B7-H1, CD274) is a coinhibitory molecule that plays a vital role in the pathogenesis of both neoplastic and nonneoplastic diseases. However, the role of PD-L1 in primary and secondary renal diseases remains to be clarified.
Yi, Wei, Zongpei, Jiang
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Prognostic significance of programmed death-1 and programmed death ligand-1 proteins in breast cancer

Human Antibodies, 2022
In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals,
Imtiaz Mahmood, Tahir, Abdur, Rauf, Huma, Mehboob, Samia, Sadaf, Muhammad Shaiful, Alam, Fadia, Kalsoom, Abdelhakim, Bouyahya, Aicha, El Allam, Nasreddine, El Omari, Saad, Bakrim, Muhammad, Akram, Syed Kashif, Raza, Talha Bin, Emran, Yahia N, Mabkhot, Gokhan, Zengin, Marina, Derkho, Suray, Natalya, Mohammad Ali, Shariati   +17 more
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Resistance mechanisms to programmed cell death protein 1 and programmed death ligand 1 inhibitors

Expert Opinion on Biological Therapy, 2021
Introduction: In the past few years, administrating monoclonal humanized antibodies, namely checkpoint inhibitors, against programmed cell death protein 1 (PD-1), and its ligand (PD-L1), has yielded reassuring tumor regression rates. Anti-PD-1/PD-L1 checkpoint inhibitors disrupt the engagement of PD-1 on T-cells and their ligands on tumor or other ...
Parmida Sadat Pezeshki, Pouya Mahdavi Sharif, Nima Rezaei   +2 more
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Mind the target: programmed death ligand 1 in oesophagogastric cancers

Current Opinion in Oncology, 2022
Purpose of review Metastatic oesophagogastric cancers carry a prognosis of generally less than 2 years despite current treatment. There has been recent excitement in the field focused on immune checkpoint inhibition though anti-PD-1 antibodies.
Luke A, Wylie, Harriet C, Baker, Elizabeth C, Smyth   +2 more
openaire   +2 more sources

The Prognostic Role of Programmed Death‐Ligand 1 in Nasopharyngeal Carcinoma

The Laryngoscope, 2020
ObjectivesProgrammed death‐ligand 1 (PD‐L1) is an immune checkpoint protein that may be a useful prognostic biomarker in nasopharyngeal cancer (NPC). The purpose of this systematic review and meta‐analysis was to investigate the relationship between PD‐L1 expression and survival in NPC.MethodsPubMed, Cochrane, Embase, Scopus, and Web of Science were ...
Michael Wotman, Saori W. Herman, Peter Costantino, Tristan Tham   +3 more
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Expression of programmed cell death ligand 1 and programmed cell death 1 in cutaneous warts

Journal of the American Academy of Dermatology, 2019
Cutaneous warts have high prevalence and cause significant morbidity. Understanding the mechanisms by which warts evade the immune system could lead to targeted and improved treatments.To determine whether cutaneous warts express programmed cell death ligand 1 (PD-L1) and to characterize the expression of programmed cell death 1 (PD-1) within the ...
Wesley Y, Yu, Timothy G, Berger, Jeffrey P, North, Zoltan, Laszik, Jarish N, Cohen   +4 more
openaire   +2 more sources