Results 51 to 60 of about 380,452 (284)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Cinnamons: A Computation Model Underlying Control Network Programming
, 2017 We give the easily recognizable name "cinnamon" and "cinnamon programming" to a new computation model intended to form a theoretical foundation for Control Network Programming (CNP).
Kratchanov, Kostadin
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
EVOLUTION OF PROGRAMMING PARADIGMS
Industrial Engineering Journal, 2022 The subject of computer programming has witnessed a wonderful journey over a long time, characterized by the continuous evolution of programming paradigms. This overview paper provides an in-depth analysis of the dynamic and difficult method through which programming paradigms have advanced from their inception to their cutting-edge kingdom. The review
Manish Kumar +3 more
openaire +1 more source
Replicode: A Constructivist Programming Paradigm and Language [PDF]
, 2013 Replicode is a language designed to encode short parallel programs and executable models, and is centered on the notions of extensive pattern-matching and dynamic code production.
Nivel, Eric, Thórisson, Kristinn R.
core
Automatically Leveraging MapReduce Frameworks for Data-Intensive Applications
, 2018 MapReduce is a popular programming paradigm for developing large-scale, data-intensive computation. Many frameworks that implement this paradigm have recently been developed.
Cheung Alvin +2 more
core +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Migrating from Developing Asynchronous Multi-Threading Programs to Reactive Programs in Java
Applied SciencesModern software application development imposes standards regarding high performance, scalability, and minimal system latency. Multi-threading asynchronous programming is one of the standard solutions proposed by the industry for achieving such ...
Andrei Zbarcea, Cătălin Tudose
doaj +1 more source