Results 51 to 60 of about 381,028 (332)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Graphical Flow-based Spark Programming
Journal of Big Data, 2020 Increased sensing data in the context of the Internet of Things (IoT) necessitates data analytics. It is challenging to write applications for Big Data systems due to complex, highly parallel software frameworks and systems.
Tanmaya Mahapatra, Christian Prehofer
doaj +1 more source
Cinnamons: A Computation Model Underlying Control Network Programming
, 2017 We give the easily recognizable name "cinnamon" and "cinnamon programming" to a new computation model intended to form a theoretical foundation for Control Network Programming (CNP).
Kratchanov, Kostadin
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Replicode: A Constructivist Programming Paradigm and Language [PDF]
, 2013 Replicode is a language designed to encode short parallel programs and executable models, and is centered on the notions of extensive pattern-matching and dynamic code production.
Nivel, Eric, Thórisson, Kristinn R.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Automatically Leveraging MapReduce Frameworks for Data-Intensive Applications
, 2018 MapReduce is a popular programming paradigm for developing large-scale, data-intensive computation. Many frameworks that implement this paradigm have recently been developed.
Cheung Alvin +2 more
core +1 more source
EVOLUTION OF PROGRAMMING PARADIGMS
Industrial Engineering Journal, 2022 The subject of computer programming has witnessed a wonderful journey over a long time, characterized by the continuous evolution of programming paradigms. This overview paper provides an in-depth analysis of the dynamic and difficult method through which programming paradigms have advanced from their inception to their cutting-edge kingdom. The review
Manish Kumar +3 more
openaire +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Dual-normal Logic Programs - the Forgotten Class
, 2015 Disjunctive Answer Set Programming is a powerful declarative programming paradigm with complexity beyond NP. Identifying classes of programs for which the consistency problem is in NP is of interest from the theoretical standpoint and can potentially ...
Fichte, Johannes K. +2 more
core +1 more source