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Role of progranulin in adipose tissue innate immunity [PDF]
Cytokine, 2020 Regulation of progranulin in adipocytes and its role in inflammation is poorly understood. Aim: (i) to investigate regulation of progranulin in adipocyte differentiation and adipose tissue compartments, (ii) to address progranulin expression in two ...
Andreas Schmid +2 more
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Progranulin in neurodegenerative disease
Trends in Neurosciences, 2014Loss-of-function mutations in the progranulin gene are a common cause of familial frontotemporal dementia (FTD). The purpose of this review is to summarize the role of progranulin in health and disease, because the field is now poised to begin examining therapeutics that alter endogenous progranulin levels.
Terri L, Petkau, Blair R, Leavitt
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The role of progranulin in arthritis
Annals of the New York Academy of Sciences, 2016Progranulin (PGRN) is a growth factor with a unique beads‐on‐a‐string structure that is involved in multiple pathophysiological processes, including anti‐inflammation, tissue repair, wound healing, neurodegenerative diseases, and tumorigenesis. This review presents up‐to‐date information concerning recent studies on the role of PGRN in inflammatory ...
Jianlu, Wei +2 more
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Progranulin antibodies in autoimmune diseases
Journal of Autoimmunity, 2013Systemic vasculitides constitute a heterogeneous group of diseases. Autoimmunity mediated by B lymphocytes and their humoral effector mechanisms play a major role in ANCA-associated vasculitis (AAV) as well as in non-ANCA associated primary systemic vasculitides and in the different types of autoimmune connective tissue disorders and rheumatoid ...
Lorenz, Thurner +13 more
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Science, 2011
A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling.
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A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling.
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Progranulin is a mediator of the wound response
Nature Medicine, 2003Annually, 1.25 million individuals suffer burns in the United States and 6.5 million experience chronic skin ulcers, often from diabetes, pressure or venous stasis. Growth factors are essential mediators of wound repair, but their success as therapeutics in wound treatment has, so far, been limited.
Zhiheng, He +3 more
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Progranulin as a therapeutic target for dementia
Expert Opinion on Therapeutic Targets, 2018Progranulin (PGRN) is an acrosomal glycoprotein that is synthesized during spermatogenesis. It is overexpressed in tumors and has anti-inflammatory properties. The protein may be cleaved into granulins which display pro-inflammatory properties. In 2006, mutations in progranulin gene (GRN) that cause haploinsufficiency were found in familial cases of ...
Daniela Galimberti +2 more
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