Results 171 to 180 of about 11,442 (213)
Some of the next articles are maybe not open access.
Science, 2011
A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling.
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A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling.
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Progranulin in neurodegenerative disease
Trends in Neurosciences, 2014Loss-of-function mutations in the progranulin gene are a common cause of familial frontotemporal dementia (FTD). The purpose of this review is to summarize the role of progranulin in health and disease, because the field is now poised to begin examining therapeutics that alter endogenous progranulin levels.
Terri L, Petkau, Blair R, Leavitt
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Progranulin, lysosomal regulation and neurodegenerative disease [PDF]
Nature Reviews Neuroscience, 2017 The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function.
Aimee W Kao +2 more
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