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Neuro-degenerative diseases, 2017
Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin gene (GRN). However, alterations of central nervous progranulin expression also occur in neurodegenerative disorders unrelated to GRN mutations, such as Alzheimer's disease.
Wilke, Carlo +10 more
openaire +3 more sources
Reduced progranulin levels are a hallmark of frontotemporal dementia (FTD) caused by loss-of-function (LoF) mutations in the progranulin gene (GRN). However, alterations of central nervous progranulin expression also occur in neurodegenerative disorders unrelated to GRN mutations, such as Alzheimer's disease.
Wilke, Carlo +10 more
openaire +3 more sources
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Nature, 2020Jiasheng Zhang +2 more
exaly
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
Nature, 2006Rosa Rademakers +2 more
exaly