Results 181 to 190 of about 7,247 (208)

[Progranulin].

Nihon rinsho. Japanese journal of clinical medicine, 2016
In central nervous system, a growth factor progranulin (PGRN) is considered to play crucial roles in maintaining physiological functions, and mutations in PGRN gene cause TDP-43-positive frontotemporal lobar degeneration. We demonstrated a dynamic change of PGRN expression in ischemic rats, including increased levels of PGRN expression in microglia ...
Masato, Kanazawa, Kunio, Kawamura, Tetsuya, Takahashi, Masatoyo, Nishizawa, Takayoshi, Shimohata   +4 more
openaire   +1 more source

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

Neurology, 2008
Mutations in the progranulin gene (PGRN) were identified as the causal mechanism underlying frontotemporal lobar degeneration (FTLD). Most of these mutations are predicted to create null alleles leading to a 50% loss of progranulin transcript.Patients underwent clinical and neurologic examination at the Memory Clinic of the IRCCS S.
R, Ghidoni, L, Benussi, M, Glionna, M, Franzoni, G, Binetti   +4 more
openaire   +2 more sources

Role of Progranulin as a Biomarker for Alzheimer's Disease

Biomarkers in Medicine, 2010
Serum or plasma progranulin (GRN) is a highly accurate of GRN-related frontotemporal lobar degeneration, which is caused by loss-of-function mutations in the GRN gene. Both null mutations and missense mutations in GRN have also been observed in patients with Alzheimer's disease.
Sleegers, Kristel, Brouwers, Nathalie, Van Broeckhoven, Christine   +2 more
openaire   +3 more sources

Progranulin function and regulation in the CNS

Trends in Neurosciences
Dysregulated progranulin expression is robustly associated with diseases of the central nervous system (CNS). Recent research has been progressing toward a mechanistic understanding of the role of progranulin in CNS disease pathophysiology. In this review we describe the consequences of dysregulated progranulin expression in experimental and disease ...
Benjamin E. Life, Blair R. Leavitt
openaire   +2 more sources

Progranulin and frontotemporal lobar degeneration

Acta Neuropathologica, 2007
Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent aphasia, regardless of the underlying neuropathological features. Considerable progress has been made in recent years in our understanding of the aetiology of this disorder, notably
openaire   +2 more sources

Progranulin Peripheral Levels as a Screening Tool for the Identification of Subjects with Progranulin Mutations in a Portuguese Cohort

Neurodegenerative Diseases, 2013
<b><i>Background:</i></b> Progranulin (PGRN) mutations are associated with different clinical phenotypes, including frontotemporal lobar degeneration (FTLD), corticobasal syndrome (CBS) and Alzheimer's disease (AD). As all pathogenic <i>PGRN</i> mutations identified so far cause disease through haploinsufficiency ...
Maria Rosário, Almeida, Inês, Baldeiras, Maria Helena, Ribeiro, Beatriz, Santiago, Cristina, Machado, João, Massano, Joana, Guimarães, Catarina, Resende Oliveira, Isabel, Santana   +8 more
openaire   +2 more sources

[Progranulin].

Nihon rinsho. Japanese journal of clinical medicine, 2012
Takeshi, Ikeuchi, Masatoyo, Nishizawa
openaire   +3 more sources

Progranulin and Inflammation/Neuroinflammation

2019
Progranulin (PGRN) and granulin (GRN) peptides are involved in peripheral inflammatory diseases and neuroinflammation. PGRN was shown to have an anti-inflammatory effect in its role as an antagonist of the TNF-α signaling pathway. On the other hand, GRN peptides stimulate immune cells to secrete pro-inflammatory cytokines.
openaire   +1 more source

Progranulin inhibition of TNFα

Immunology & Cell Biology, 2014
Sardar M Z, Uddin, Jyoti Joshi, Mundra, Jinlong, Jian, Qingyun, Tian, Elena, Gonzalez-Gugel, Brendon, Richbourgh, Chuan-ju, Liu   +6 more
openaire   +2 more sources

Progranulin-Antikörper und hyperphosphoryliertes Progranulin in Vaskulitiden, Kollagenosen und Myositiden

2019
Autoantikörper spielen eine große Rolle in der Diagnostik und Pathogenese von Vaskulitiden und Kollagenosen. So haben antineutrophile zytoplasmatische Antikörper (ANCA) nicht nur eine Rolle in der Diagnostik der ANCA-assoziierten Vaskulitiden, sondern besitzen auch einen besonderen pathogenetischen Stellenwert.
openaire   +1 more source