Results 51 to 60 of about 270,485 (267)

A Tale of Two Countries and One School District

Nonpartisan Education Review, 2006
no ...
Barry Garelick
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

21st Century Competencies in Light of the History of Integrated Curriculum

Frontiers in Education, 2020
Integrated or interdisciplinary curriculum (IC) is an effective and relevant way to teach the 21st century competencies and to apply the transdisciplinary skills necessary for solving complex global problems.
Susan M. Drake, Joanne L. Reid
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Jo Boaler’s Fame, Stanford’s Shame； Students’ Gloom, America’s Doom, Part 2 [PDF]

Nonpartisan Education Review, 2021
Rooted in Profound Anti-intellectualism, Elitism, Racial and Gender Prejudice, the 2021 California Math Framework Threatens to Undermine Math Learning for All Students and Leave Disadvantaged Learners Permanently Behind.
Ling Huang
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

What is the Integral in Integral Education? From Progressive Pedagogy to Integral Pedagogy [PDF]

Integral Review, 2009
Integrally-informed educational approaches have much in common withprogressive (including reform, alternative, holistic, and transformative) approaches, andshare many of the same values.
Tom Murray
doaj  

Jo Boaler’s Fame, Stanford’s Shame; Students’ Gloom, America’s Doom, Part 1 [PDF]

Nonpartisan Education Review, 2021
Rooted in Profound Anti-intellectualism, Elitism, Racial and Gender Prejudice, the 2021 California Math Framework Threatens to Undermine Math Learning for All Students and Leave Disadvantaged Learners Permanently Behind.
Ling Huang
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Validation of the Teacher Questionnaire of Montessori Practice for Early Childhood in the Dutch Context

Journal of Montessori Research
Montessori education has existed for more than 100 years and counts almost 16,000 schools worldwide (Debs et al., 2022). Still, little is known about the implementation and fidelity of Montessori principles.
Jaap de Brouwer, Vivian Morssink-Santing, Symen van der Zee   +2 more
doaj   +1 more source