Results 51 to 60 of about 269,896 (266)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A Tale of Two Countries and One School District
Nonpartisan Education Review, 2006 no ...
Barry Garelick
doaj
21st Century Competencies in Light of the History of Integrated Curriculum
Frontiers in Education, 2020 Integrated or interdisciplinary curriculum (IC) is an effective and relevant way to teach the 21st century competencies and to apply the transdisciplinary skills necessary for solving complex global problems.
Susan M. Drake, Joanne L. Reid
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Jo Boaler’s Fame, Stanford’s Shame； Students’ Gloom, America’s Doom, Part 2 [PDF]
Nonpartisan Education Review, 2021 Rooted in Profound Anti-intellectualism, Elitism, Racial and Gender Prejudice, the 2021 California Math Framework Threatens to Undermine Math Learning for All Students and Leave Disadvantaged Learners Permanently Behind.
Ling Huang
doaj
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
What is the Integral in Integral Education? From Progressive Pedagogy to Integral Pedagogy [PDF]
Integral Review, 2009 Integrally-informed educational approaches have much in common withprogressive (including reform, alternative, holistic, and transformative) approaches, andshare many of the same values.
Tom Murray
doaj
Jo Boaler’s Fame, Stanford’s Shame; Students’ Gloom, America’s Doom, Part 1 [PDF]
Nonpartisan Education Review, 2021 Rooted in Profound Anti-intellectualism, Elitism, Racial and Gender Prejudice, the 2021 California Math Framework Threatens to Undermine Math Learning for All Students and Leave Disadvantaged Learners Permanently Behind.
Ling Huang
doaj
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Journal of Montessori ResearchMontessori education has existed for more than 100 years and counts almost 16,000 schools worldwide (Debs et al., 2022). Still, little is known about the implementation and fidelity of Montessori principles.
Jaap de Brouwer +2 more
doaj +1 more source