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Molecular characterization of JC virus in progressive multifocal leukoencephalopathy cases from India. [PDF]

Sci Rep
Palani GS, Telang S, Reddy V, Dhanya K, Ashwini MA, Mani RS.   +5 more
europepmc   +1 more source

Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy.

JAMA Neurol
Möhn N, Grote-Levi L, Bonifacius A, Tischer-Zimmermann S, Nay S, Jendretzky KF, Sassmann ML, Karacondi K, Zent M, Konen FF, Sühs KW, Meuth SG, Pawlitzki M, Warnke C, Ayzenberg I, Schneider R, Helmchen C, Brüggemann N, Klebe S, Hildner M, Grefkes C, Nitsch L, Hühnchen P, Böltz S, Alt L, Tumani H, Kleinschnitz C, Pul R, Grauer O, Clifford D, Gnanapavan S, Wicklein R, Perpoint T, Beudel M, Del Bello A, Rauer S, Wiendl H, Jelcic I, Gasnault J, Cimini E, Antinori A, Pinnetti C, Pourcher V, Weiss N, Lambert N, Maecker-Kolhoff B, Höglinger GU, Zahraeifard S, Cortese I, Eiz-Vesper B, Martin-Blondel G, Skripuletz T, Immunotherapy for PML Study Group.   +52 more
europepmc   +1 more source

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The emergence of progressive multifocal leukoencephalopathy (PML) in rheumatic diseases

Journal of Autoimmunity, 2008
Progressive multifocal leukoencephalopathy (PML) is a rare and devastating neurological disease with areas of demyelination in the central nervous system classically associated with profound imunosuppression. PML is caused by reactivation of latent JC virus, leading to the death of myelin-producing oligodendrocytes typically with a rapidly fatal ...
M Eric Gershwin, Stanley M Naguwa
exaly   +3 more sources

Progressive Multifocal Leukoencephalopathy (PML)

2014
Progressive multifocal leukoencephalopathy (PML) was first considered a distinct neurological entity in 1958. Its neuropathology is represented by multifocal demyelinating lesions accompanying oligodendroglia-like cells with markedly enlarged nuclei. Electron microscopy in 1965 showed polyomavirus-like structures in the enlarged nuclei.
exaly   +2 more sources

Progressive multifocal leukoencephalopathy (PML) associated with HIV Clade C—is not uncommon

Journal of NeuroVirology, 2013
Progressive multifocal leukoencephalopathy (PML) is a rare, subacute, demyelinating disease of the central nervous system caused by JC virus. Studies of PML from HIV Clade C prevalent countries are scarce. We sought to study the clinical, neuroimaging, and pathological features of PML in HIV Clade C patients from India.
Thennarasu Kandavel, Netravathi M, Parthasarathy Satishchandra   +2 more
exaly   +3 more sources

Spontaneous progressive multifocal leukoencephalopathy (PML) in macaques

Nature, 1975
PROGRESSIVE multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) which has so far been recognised only in man1,2. Although it is an infrequent cause of clinical neurological disorder3, it is of particular interest because of its frequent association with diseases in which immunological competence is ...
D H, Gribble, C C, Haden, L W, Schwartz, R V, Henrickson   +3 more
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Are astrocytes infected in progressive multifocal leukoencephalopathy (PML)?

Acta Neuropathologica, 1982
Ultrastructural characteristics of the early steps of PML virus infection, i.e. adsorption, penetration, and intracellular virus transport were demonstrated in astrocytes. These phenomena were more frequently seen in the cytoplasm than virus assembly in the nuclei. Infection of the astrocytes is usually non-productive.
M, Mázló, I, Tariska
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Progressive multifocal leukoencephalopathy (PML)

Neurology, 1980
Cell-mediated immunity was studied by in vitro tests in seven patients with progressive multifocal leukoencephalopathy (PML). Lymphocyte proliferation in response to mitogenic stimulation was reduced to a variable degree in all patients, indicating a general impairment of cell-mediated immune responsiveness, although mitogen-induced production of the ...
E, Willoughby, R W, Price, B L, Padgett, D L, Walker, B, Dupont   +4 more
openaire   +2 more sources

AIDS‐associated progressive multifocal leukoencephalopathy (PML)

Neurology, 1990
We studied brain sections from 10 patients with the acquired immunodeficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML) by in situ hybridization with a biotin-labeled JC virus (JCV) DNA probe and by immunohistochemistry using antibody against the JCV capsid antigen.
A J, Aksamit, H E, Gendelman, J M, Orenstein, G H, Pezeshkpour   +3 more
openaire   +2 more sources