Results 1 to 10 of about 15,662 (181)

Emerging Hypersexuality in a Patient With Progressive Supranuclear Palsy [PDF]

BJPsych Open
Aims: Progressive supranuclear palsy (PSP) typically presents with a constellation of motor symptoms, most commonly with frequent falls and gait disturbances.
Lim P, Chai B.
europepmc   +2 more sources

4R-tau seeding activity reveals molecular subtypes in progressive supranuclear palsy. [PDF]

Nat Commun
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by abnormal accumulation of the protein tau in the brain, leading to motor and cognitive symptoms that vary between individuals. The reasons for this clinical heterogeneity
Martinez-Valbuena I, Lee S, Santamaria E, Fernández-Irigoyen J, Forrest SL, Zampar S, Li J, Tanaka H, Couto B, Gil D Reyes N, Qamar SH, Karakani AM, Kim A, Senkevich K, Rogaeva E, Fox SH, Tartaglia MC, Visanji NP, Ingelsson M, Andrews T, Lang AE, Kovacs GG.   +21 more
europepmc   +2 more sources

Progressive supranuclear palsy [PDF]

Seminars in Neurology, 2001
Unfortunately, no drug treatment has been shown to benefit patients with progressive supranuclear palsy (PSP) more than modestly or briefly. The multiplicity of neuronal systems and synaptic physiologies that degenerate in this disorder makes a neurotransmitter-specific approach, such as neurotransmitter replacement or reuptake inhibition, unlikely to ...
K, Tawana, D B, Ramsden
openaire   +5 more sources

Progressive supranuclear palsy [PDF]

Postgraduate Medical Journal, 2000
Abstract Progressive supranuclear palsy (PSP) or Steele-Richardson-Olszewski syndrome is a neurodegenerative disease of middle and late age. It is under-diagnosed not only by general physicians but also by neurologists. The cause of PSP is not known.
, Lowrey, , Wong
openaire   +4 more sources

Clinical Features of Patients With Progressive Supranuclear Palsy in an US Insurance Claims Database

Frontiers in Neurology, 2021
Background: Progressive supranuclear palsy is a rare neurodegenerative movement disorder and little is known about its epidemiology.Objective: Estimate age-adjusted prevalence of progressive supranuclear palsy and describe antecedent diagnoses and ...
Emma Viscidi, Irene Litvan, Tien Dam, Maneesh Juneja, Li Li, Henry Krzywy, Susan Eaton, Susan Hall, Joseph Kupferman, Günter U. Höglinger, Günter U. Höglinger, Günter U. Höglinger   +11 more
doaj   +1 more source

Umbilical cord blood stem cells transplantation in a patient with severe progressive supranuclear palsy: a case report

Journal of Medical Case Reports, 2021
Background Progressive supranuclear palsy is a neurodegenerative condition that worsens over time. Given the lack of targeted treatments, patients with severe progressive supranuclear palsy have very low life expectancy.
Huiping Li, Fang Yuan, Yaming Du, Tao Pan, Wanxin Wen, Shaoxue Li, Lixin Wang, Aili Lu   +7 more
doaj   +1 more source

Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy

NeuroImage: Clinical, 2021
Progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex.
Irene Sintini, Kenton Kaufman, Hugo Botha, Peter R. Martin, Stacy R. Loushin, Matthew L. Senjem, Robert I. Reid, Christopher G. Schwarz, Clifford R. Jack Jr, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell, Farwa Ali   +12 more
doaj   +1 more source

The Significance of Asymmetry in the Assessment of Brain Perfusion in Atypical Tauopathic Parkinsonian Syndromes

Diagnostics, 2022
Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) are clinical manifestations of tauopathic Parkinsonian syndromes. Due to their overlapping symptomatology, the differential diagnosis of these entities may be difficult when ...
Piotr Alster, Natalia Madetko, Bartosz Migda, Michał Nieciecki, Michał Kutyłowski, Leszek Królicki, Andrzej Friedman   +6 more
doaj   +1 more source

Progressive supranuclear palsy

Hospital Medicine, 2003
Progressive supranuclear palsy, also known as Steele–Richardson–Olszewski syndrome, is an uncommon neurodegenerative parkinsonian disorder that starts in middle and late life, and is frequently misdiagnosed as Parkinson's disease. This review will cover the epidemiology, clinical picture, differential diagnosis and management of patients with ...
Douglas G. Cole, Nutan Sharma
  +5 more sources

9.4 T MR microscopy of the substantia nigra with pathological validation in controls and disease

NeuroImage: Clinical, 2017
Background: The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures.
LA Massey, MA Miranda, O Al-Helli, HG Parkes, JS Thornton, P-W So, MJ White, L Mancini, C Strand, J Holton, AJ Lees, T Revesz, TA Yousry   +12 more
doaj   +1 more source