Results 71 to 80 of about 33,332 (299)

Advances in diagnosis and treatment of progressive supranuclear palsy and interpretation of new diagnostic criteria

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Recently, both the paper "Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches" in Lancet Neurol and "Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria" in ...
Jin-tai YU, Chen-chen TAN, Lan TAN
doaj  

Pyramidal system involvement in progressive supranuclear palsy – a clinicopathological correlation

BMC Neurology, 2019
Background We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP).
Zuzana Stejskalova, Zdenek Rohan, Robert Rusina, Adam Tesar, Jaromir Kukal, Gabor G. Kovacs, Ales Bartos, Radoslav Matej   +7 more
doaj   +1 more source

Bedside Assessment of Downgaze Limit by Amplitude

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Bedside assessment of downgaze palsy could be difficult, due to the lack of a marker to differentiate normal from palsy, which could delay the diagnosis of progressive supranuclear palsy (PSP). Amplitude based bedside assessment using the intercanthal line as a marker was reported to easily identify, quantify, and record downgaze ...
Tao Xie, Mahesh Padmanaban, John Collins, Chuanhong Liao, Widad Abou Chaar, Jonathan Bundy, Jeffrey Nichols   +6 more
wiley   +1 more source

Clinical heterogeneity of progressive supranuclear palsy

Анналы клинической и экспериментальной неврологии, 2018
Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative disease characterized by oculomotor disorders, early onset of postural instability and cognitive dysfunction.
Alexey A. Tappakhov, Tatiana E. Popova, Tatiana G. Govorova, Alyona Yu. Petrova   +3 more
doaj   +1 more source

Magnetic Susceptibility and Area in the Subthalamic Nucleus Measured by QSM for Diagnosis of Progressive Supranuclear Palsy. [PDF]

Mov Disord Clin Pract
Abstract Background Iron deposition and atrophy of the subthalamic nucleus (STN) have been reported in progressive supranuclear palsy (PSP). Quantitative susceptibility mapping (QSM), an advanced MRI technique, enables noninvasive assessment of the magnetic susceptibility of biological tissue and has been reported to have good ability to delineate STN.
Haji S, Sako W, Hanada K, Matsubara T, Osaki Y, Matsumoto Y, Harada M, Izumi Y.   +7 more
europepmc   +2 more sources

Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials [PDF]

, 2023
The advent of clinical trials of disease-modifying agents for neurodegenerative disease highlights the need for evidence-based endpoint selection.
Allinson, Kieren SJ, Ansorge, Olaf, Bocchetta, Martina, Burn, David J, Chelban, Viorica, Church, Alistair, Costantini, Alyssa, Gerhard, Alexander, Goh, Yen Y, Guo, Tong, Heslegrave, Amanda J, Holland, Negin, Houlden, Henry, Hu, Michele TM, Jabbari, Edwin, Jaunmuktane, Zane, Jensen, Marte T, Jones, P Simon, Klein, Johannes C, Kobylecki, Christopher, Lees, Andrew J, Leigh, P Nigel, Morris, Huw, Pavese, Nicola, Revesz, Tamas, Rittman, Timothy, Rohrer, Jonathan D, Roncaroli, Federico, Rowe, James B, Russell, Lucy L, Street, Duncan, Warner, Thomas T, Zetterberg, Henrik   +32 more
core  

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. [PDF]

PLoS ONE, 2018
Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau.
Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasson   +6 more
doaj   +1 more source

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

Dysphagia in Progressive Supranuclear Palsy

Dysphagia, 2019
Progressive supranuclear palsy (PSP) is the most common Parkinson-Plus syndrome and is associated with early onset of dysphagia relative to Parkinson Disease. The current study contributes to the growing understanding of swallowing dysfunction in PSP by describing oropharyngeal swallowing characteristics in a large prospective cohort of participants ...
Heather M. Clark, Farwa Ali, Julie A.G. Stierwalt, Nirubol Tosakulwong, Jennifer L. Whitwell, Keith A. Josephs, Hugo Botha   +6 more
openaire   +4 more sources

Efficacy and Safety of IncobotulinumtoxinA for Treatment of Sialorrhea: A Multicenter, Phase 3 Study in Japan

Movement Disorders Clinical Practice, EarlyView.
This study demonstrated significant treatment efficacy and safety of incobotulinumtoxinA injection in Japanese patients with chronic sialorrhea caused by Parkinson's disease and other neurological conditions. Suppression of salivary secretion and improvement in drooling symptoms were also observed throughout 48 weeks.
Nobutaka Hattori, Yohei Mukai, Noriko Nishikawa, Kazuko Hasegawa, Masahiko Tomiyama, Yasuyoshi Kimura, Yoshio Tsuboi, Ryosuke Takahashi, Ryota Nakamura, Yuishin Izumi, Hirohisa Watanabe, Morinobu Seki, Kenji Sekiguchi, Shohei Tateishi, Yusaku Matsushita, Yusaku Nakamura   +15 more
wiley   +1 more source